55104-60-4Relevant academic research and scientific papers
Rhodium-Catalyzed Twofold Unsymmetrical C-H Alkenylation-Annulation/Thiolation Reaction to Access Thiobenzofurans
Lin, Jian,Hu, Liuyu,Chen, Chao,Feng, Huijin,Yu, Yang,Yang, Yaxi,Zhou, Bing
supporting information, p. 1194 - 1198 (2021/02/20)
A Rh(III)-catalyzed twofold unsymmetrical C-H alkenylation-annulation/thiolation reaction has been developed, enabling the straightforward and efficient synthesis of various thiobenzofurans in one step. This robust protocol proceeds with a broad substrate scope and good functional group tolerance under relatively mild reaction conditions.
Macrocyclic Compounds Useful as Bace Inhibitors
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Page/Page column 26, (2008/12/05)
The invention relates to novel macrocyclic compounds of the formula (I), in which all of the variables are as defined in the specification, the number of ring atoms included in the macrocyclic ring being 14, 15, 16 or 17, in free base form or in acid addition salt form, to their preparation, to their use as medicaments and to medicaments comprising them.
SYNTHESIS OF 4-ALKENYL-3,5-DIMETHOXYBENZOIC ACIDS BY CLAISEN REARRANGEMENT
Occelli, Emilio,DePaoli, Adele,Nathansohn, Giangiacomo
, p. 383 - 390 (2007/10/02)
Methyl 3-allyloxy-5-methoxybenzoate (1a) and its methyl homologues on the α, β and γ carbon atoms (1b,c,d) have been subjected to Claisen rearrangement.The structures of the rearranged products have been determined and the factors affecting the isomeric r
2,4,6-Trisubstituted-2,3-dihydro-benzofuran derivatives
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, (2008/06/13)
New 2,4,6-trisubstituted-2,3-dihydro-benzofuran derivatives of the following general formula STR1 wherein R is selected from hydrogen or methyl; one of R1 and R2 represents hydroxy, (C1-4)alkoxy or (C2-4)alkanoyloxy, and the other one is selected from cyano, carboxy, carbo(C1-4)alkoxy, carbamoyl and a --NR3 R4 group, wherein R3 and R4 independently represent hydrogen (C1-4)alkyl, (C2-4)alkanoyl, carbo(C1-4)alkoxy, carbobenzyloxy, carbamoyl, mono- and di-(C1-4)alkylamino-(C1-4)alkyl, benzenesulfonyl, toluenesulfonyl, (C1-4)alkylsulfonyl or phenacylsulfonyl; and salts therewith of pharmaceutically acceptable acids. The compounds have antinflammatory, analgesic and antipyretic utility.
AMINOPROPANOL SUBSTITUTED ISOCHROMANONES AND PHTHALIDES
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, (2008/06/13)
Aminopropanols with β-blocking activity having the general formula SPC1Wherein R is hydrogen, C 1-C 4 alkyl or hydroxy-(C 2-C 4) alkyl, R 1 is C 1-C 4 alkyl or hydroxy-(C 2-C 4) alkyl; R 2 and R 3 each independently represent hydrogen or C 1-C 2 alk
