19520-74-2Relevant articles and documents
Structural and thermodynamic studies on cation-II interactions in lectin-ligand complexes: High-affinity galectin-3 inhibitors through fine-tuning of an arginine-arene interaction
Soerme, Pernilla,Arnoux, Pascal,Kahl-Knutsson, Barbro,Leffler, Hakon,Rini, James M.,Nilsson, Ulf J.
, p. 1737 - 1743 (2005)
The high-resolution X-ray crystal structures of the carbohydrate recognition domain of human galectin-3 were solved in complex with N-acetyllactosamine (LacNAc) and the high-affinity inhibitor, methyl 2-acetamido-2-deoxy-4-O-(3-deoxy-3-[4-methoxy-2,3,5,6-tetrafluorobenzamido] -β-D-galactopyranose)-β-D-glucopyranoside, to gain insight into the basis for the affinity-enhancing effect of the 4-methoxy-2,3,5,6- tetrafluorobenzamido moiety. The structures show that the side chain of Arg144 stacks against the aromatic moiety of the inhibitor, an interaction made possible by a reorientation of the side chain relative to that seen in the LacNAc complex. Based on these structures, synthesis of second generation LacNAc derivatives carrying aromatic amides at 3′-C, followed by screening with a novel fluorescence polarization assay, has led to the identification of inhibitors with further enhanced affinity for galectin-3 (Kd ≥ 320 nM). The thermodynamic parameters describing the binding of the galectin-3 C-terminal to selected inhibitors were determined by isothermal titration calorimetry and showed that the affinity enhancements were due to favorable enthalpic contributions. These enhancements could be rationalized by the combined effects of the inhibitor aromatic structure on a cation-Π interaction and of direct interactions between the aromatic substituents and the protein. The results demonstrate that protein-ligand interactions can be significantly enhanced by the fine-tuning of arginine-arene interactions.
The synthesis of dendroflorin
Deng, Yi,Jiang, Kun,Cai, Mao-Jun,Qu, Shi-Jin,Dai, Yi-Ru,Tan, Chang-Heng
, p. 602 - 609 (2017/05/26)
The first synthesis of dendroflorin has been achieved in 10 steps with an overall yield of 5.5%. The key step in the synthesis features the biphenyl structure is built through Suzuki–Miyaura reaction. In addition, the ortho-localization effect induced by aromatic substituent during the bromination of intermediate 8 is also observed and discussed.
Total synthesis of the resveratrol oligomers (±)-Ampelopsin B and (±)-σ-Viniferin
Lindgren, Anders E. G.,?berg, Christopher T.,Hillgren, J. Mikael,Elofsson, Mikael
supporting information, p. 426 - 429 (2016/02/18)
The total synthesis of the resveratrol dimers (±)-ampelopsin B and (±)-σ-viniferin is reported. Highlights of the approach include the use of cyclopropylmethyl groups to protect aromatic alcohols. This group allows an acid promoted three-step, one-pot dep
