55119-00-1Relevant academic research and scientific papers
Preparation method and intermediate of hexahydroquinolinedione compound
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Paragraph 0066; 0073-0076, (2020/02/29)
The invention discloses a preparation method and an intermediate of a hexahydroquinolinedione compound. A compound represented by formula I undergoes a hydrolysis reaction shown in the description inthe presence of an acid to obtain the compound represent
TETRAHYDROQUINOLINONES AND THEIR USE AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS
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Page/Page column 27, (2008/06/13)
The invention relates to ethynyl-substituted tetrahydroquinolinone derivatives as well as their pharmaceutically acceptable a salts. The invention further relates to a process for the preparation of such compounds. The compounds of the invention are group
TETRAHYDROQUINOLINONES AND THEIR USE AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS
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Page/Page column 27, (2008/06/13)
The invention relates to ethynyl-substituted tetrahydroquinolinone derivatives as well as their pharmaceutically acceptable salts. The invention further relates to a process for the preparation of such compounds. The compounds of the invention are group I
TETRAHYDROQUINOLINONES AND THEIR USE AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS
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Page/Page column 36, (2008/06/13)
The invention relates to tetrahydroquinolinone derivatives as well as their pharmaceutically acceptable salts. The invention further relates to a process for the preparation of such compounds. The compounds of the invention are group I mGIuR modulators an
ACETALS OF LACTAMS AND ACID AMIDES. 48. REACTION OF ENAMINO DIKETONES WITH AMIDE ACETALS. SYNTHESIS OF DERIVATIVES OF COUMARIN AND CARBOSTYRIL
Grannik, V. G.,Shanazarov, A. K.,Solov'eva, N. P.,Chistyakov, V. V.,Persianova, I. V.,Sheinker, Yu. N.
, p. 1171 - 1177 (2007/10/02)
It was established that the reaction of derivatives of 2-aminomethylenecyclohexane-1,3-dione with N,N-dimethyl-diethylacetal gives dienediamines, heating of which in aqueous hydrochloric acid leads, depending on the structure, to derivatives of carbostyri
Reaction of 2-Dimethylaminomethylene-1,3-diones with Dinucleophiles.V. Synthesis of 5-Acyl-1,2-dihydro-2-oxo-3-pyridinecarbonitriles and 1,2,5,6,7,8-Hexahydro-2,5-dioxo-3-quinolinecarboxamides
Mosti, Luisa,Schenone, Pietro,Menozzi, Giulia
, p. 1503 - 1509 (2007/10/02)
The reaction of open-chain sym-2-dimethylaminomethylene-1,3-diones Ia-d with sodium cyanoacetamide gave, generally in good yields, 6-substituted 5-acyl-1,2-dihydro-2-oxo-3-pyridinecarbonitriles IIa-d, whereas cyclohexane sym-2-dimethylaminomethylene-1,3-diones Ie-h afforded in general a mixture of 1,2,5,6,7,8-hexahydro-2,5-dioxo-3-quinolinecarbonitriles and 5,6,7,8-tetrahydro-2,5-dioxo-2H-1-benzopyran-3-carboxamides, the latter being isolated in two cases.The reaction of Ie-h with cyanoacetamide in refluxing anhydrous ethanol gave 1,2,5,6,7,8-hexahydro-2,5-dioxo-3-quinolinecarboxamides IIIe-h in excellent yields, whereas Ia-d did not react with the exception of Ia which afforded in good yield 3-pyridinecarboxamide IIIa.Other 3-pyridinecarboxamides were obtained by partial hydrolysis of nitriles IIb,d. 3-Pyridine and 3-quinoline carboxamides were hydrolyzed in satisfactory yields with hydrochloric acid to the corresponding carboxylic acids, which were decarboxylated in good yields to 5-acyl-2(1H)-pyridinones and 7,8-dihydro-2,5-(1H,6H)-quinolinediones, respectively, by reflux in quinoline containing a catalytic amount of copper powder.
