55120-10-0

Upstream product

• 4692-98-2 5-bromoisatoic anhydride 
• 100-63-0 phenylhydrazine 

Downstream Products

• 1374601-05-4 7'-bromo-3a'-methyl-4'-(phenylamino)-3a',4'-dihydro-1'H-spiro[cyclopentane-1,2'-pyrrolo[1,2-a]quinazoline]-1',5'(3'H)-dione 
• 1374600-90-4 7-bromo-3a-methyl-4-(phenylamino)-1H,2H,3H,3aH,4H,5H-pyrrolo[1,2-a]quinazoline-1,5-dione 
• 1374601-10-1 7-bromo-3a-ethyl-4-(phenylamino)-2,3,3a,4-tetrahydropyrrolo[1,2-a]-quinazoline-1,5-dione 
• 1374601-01-0 3-bromo-6a-methyl-6-(phenylamino)-6,6a-dihydroisoindolo[2,1-a]-quinazoline-5,11-dione 
• 1437780-41-0 9-bromo-5-phenylindazolo[3,2-b]quinazolin-7(5H)-one 
• 1600520-00-0 7-bromo-1,2-diphenylpyrazolo[5,1-b]quinazolin-9(1H)-one 

Relevant academic research and scientific papers

Synthesis of quaternary carbon-centered indolo[1,2-a]quinazolinones and indazolo[1,2-a]indazolonesviaC-H functionalization

An unprecedented Ru(ii)-catalyzed Csp2-H bond activation and annulation reaction of phenylindazolones with diaryl-substituted alkynes and dialkyl-substituted alkynes provided efficient routes for the construction of all-carbon quaternary-centered indolo[1,2-a]quinazolinones and quaternary carbon-centered indazolo[1,2-a]indazolones, respectively. The indolo[1,2-a]quinazolinones were fomedviaCsp2-H activation, alkyne insertion and a 1,2-phenyl shift. Indazolo[1,2-a]indazolones were formed through a cascade reactionviathe formation of exocyclic double bonds containing indolo[1,2-a]quinazolinones.

New linearly and angularly fused quinazolinones: Synthesis through gold(I)-catalyzed cascade reactions and anticancer activities

A robust library-based approach to new fused quinazolinones by the development of gold(I)-catalyzed cascade reactions between 2- aminobenzohydrazides and alkynoic acids is documented. Selected compounds were administered to lung (A549) and breast cancer cells (MDA-MB-231 and MCF-7) in vitro and it was found that some successfully inhibited cell proliferation.