55124-71-5Relevant academic research and scientific papers
From simple to complex: Rhodium(III)-catalyzed C-C bond cleavage and C-H bond functionalization for the synthesis of 3a, 8b- dihydro-1H-cyclopenta[b]benzofuran-1-ones
Guo, Guiyu,Wan, Saihong,Si, Xiaodong,Jiang, Qijian,Jia, Yuanyuan,Yang, Luo,Zhou, Wang
, p. 5026 - 5029 (2017)
A rhodium(III)-catalyzed strategy for the onestep synthesis of polysubstituted cis-3a, 8b-dihydro-1Hcyclopenta[ b]benzofuran-1-ones from simple 2′-hydroxychalcones and alkynes is developed. This novel transformation involves a sequential C-C bond cleavage and dehydrogenative annulation, leading to the product bearing a quaternary and a tertiary carbon center. 13C labeling experiments revealed that C-C bond cleavage takes place not only at the C-C(C-O) bond but also at the C-C bond. This study provides an alternative strategy using C-C bond cleavage thus demonstrating the power of this strategy combined with C-H bond functionalization for assembling complex structures from simple starting materials.
Synthesis of deuterium-labeled flavanones
Kagawa, Hitoshi,Takahashi, Tetsuya,Uno, Mariko,Ohta, Shigeru,Harigaya, Yoshihiro
, p. 953 - 956 (2007/10/03)
Deuterium incorporation at the C-3 position of flavanones was achieved by treatment of flavanones and 2′-hydroxychalcones with D3PO 4 and AcOD. We propose that the deuteration reaction mechanism for 2′-hydroxychalcones substrates is
