55130-19-3

Basic information

• Product Name: di-tert-butyl dicarbonate
• Synonyms: di-tert-butyl dicarbonate
• CAS NO: 55130-19-3
• Molecular Weight: 204.223
• Mol File: 55130-19-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: di-tert-butyl dicarbonate(CAS DataBase Reference)
• NIST Chemistry Reference: di-tert-butyl dicarbonate(55130-19-3)
• EPA Substance Registry System: di-tert-butyl dicarbonate(55130-19-3)

Safety Data

• Hazardous Substances Data: 55130-19-3(Hazardous Substances Data)

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 67-63-0 isopropyl alcohol 

Downstream Products

• 675834-17-0 methyl 1-benzyl-3-((tert-butoxycarbonyl)amino)pyrrolidine-3-carboxylate 
• 1219097-38-7 C₂₄H₃₀FN₃O₆ 
• 1219495-03-0 C₂₄H₂₉BF₃N₃O₆ 
• 120737-59-9 3-methyl-piperazine-1-carboxylic acid tert-butyl ester 
• 324784-91-0 1-t-butoxycarbonyl-4-(4-chlorophenyl)-4-hydroxyhomopiperidine 

Relevant articles and documents

Di-tert-butyl dicarbonate and 4-(dimethylamino)pyridine revisited. Their reactions with amines and alcohols

The reaction of BOC2O in the presence and absence of DMAP was examined with some amines, alcohols, diols, amino alcohols, and aminothiols. Often, unusual products were observed depending on the ratio of reagents, reaction time, polarity of solvent, pK(a) of alcohols, or type of amine (primary or secondary). In reactions of aliphatic alcohols with BOC2O/DMAP, we isolated for the first time carbonic-carbonic anhydride intermediates; this helps explain the formation of symmetrical carbonates in addition to the O-BOC products. In the case of secondary amines, we succeeded to isolate unstable carbamic-carbonic anhydride intermediates that in the presence of DMAP led to the final N-BOC product. The effect of N-methylimidazole in place of DMAP was also examined.