55138-19-7

Upstream product

• 585-79-5 m-nitrobromobenzene 
• 302-01-2 hydrazine 
• 318514-93-1 (E)-1,2-bis-(3-bromophenyl)diazene 
• 591-19-5 m-Bromoaniline 
• 63213-03-6 1,2-bis(3-bromophenyl)diazene 
• 23377-24-4 bis-(3-bromo-phenyl)-diazene-N-oxide 

Downstream Products

• 84530-60-9 2,2'-dibromo-[1,1'-biphenyl]-4,4'-diamine 
• 63213-03-6 1,2-bis(3-bromophenyl)diazene 
• 34913-29-6 4,4′-bis(trifluoromethyl)azobenzene 
• 2415-99-8 4.4'-Di-(4-decyloxy-benzylidenamino)-2.2'-dibrom-biphenyl 
• 2415-98-7 4.4'-Di-(4-nonyloxy-benzylidenamino)-2.2'-dibrom-biphenyl 
• 4550-71-4 4.4'-Di-(4-octyloxy-benzylidenamino)-2.2'-dibrom-biphenyl 
• 3406-99-3 4.4'-Di-(4-heptyloxy-benzylidenamino)-2.2'-dibrom-biphenyl 

Relevant academic research and scientific papers

Visible-Light-Promoted Diboron-Mediated Transfer Hydrogenation of Azobenzenes to Hydrazobenzenes

A visible-light-promoted transfer hydrogenation of azobenzenes has been developed. In the presence of B2pin2 and upon visible-light irradiation, the reactions proceeded smoothly in methanol at ambient temperature. The azobenzenes with diverse functional groups have been reduced to the corresponding hydrazobenzenes with a yield of up to 96%. Preliminary mechanistic studies indicated that the hydrogen atom comes from the solvent and the transformation is achieved through a radical pathway.

Synthesis of novel 1,2-diarylpyrazolidin-3-one–based compounds and their evaluation as broad spectrum antibacterial agents

There is a continuous need to develop new antibacterial agents with non-traditional mechanisms to combat the nonstop emerging resistance to most of the antibiotics used in clinical settings. We identified novel pyrazolidinone derivatives as antibacterial hits in an in-house library screening and synthesized several derivatives in order to improve the potency and increase the polarity of the discovered hit compounds. The oxime derivative 24 exhibited promising antibacterial activity against E. coli TolC, B. subtilis and S. aureus with MIC values of 4, 10 and 20 μg/mL, respectively. The new lead compound 24 was found to exhibit a weak dual inhibitory activity against both the E. coli MurA and MurB enzymes with IC50 values of 88.1 and 79.5 μM, respectively, which could partially explain its antibacterial effect. A comparison with the previously reported, structurally related pyrazolidinediones suggested that the oxime functionality at position 4 enhanced the activity against MurA and recovered the activity against the MurB enzyme. Compound 24 can serve as a lead for further development of novel and safe antibiotics with potential broad spectrum activity.

Visible-light-promoted oxidative dehydrogenation of hydrazobenzenes and transfer hydrogenation of azobenzenes

Azo compounds are widely used in the pharmaceutical and chemical industries. Here, we report the use of a non-metal photo-redox catalyst, Eosin Y, to synthesize azo compounds from hydrazine derivatives. The use of visible-light with air as the oxidant makes this process sustainable and practical. Moreover, the visible-light-driven, photo-redox-catalyzed transfer hydrogenation of azobenzenes is compatible with a series of hydrogen donors such as phenyl hydrazine and cyclic amines. Compared with traditional (thermal/transition-metal) methods, our process avoids the issue of over-reduction to aniline, which extends the applicability of photo-redox catalysis and confirms it as a useful tool for synthetic organic chemistry.

Tin-mediated reduction of azoarenes to hydrazoarenes using hydrazine hydrate

The controlled reduction of azoarenes to the corresponding hydrazoarenes using tin and hydrazine hydrate is reported. The reduction proceeds smoothly at room temperature furnishing the hydrazoarene in excellent yield without the formation of an aniline.

Ammonium chloride mediated reduction of azo compounds to hydrazo compounds

The reduction of azo compounds with magnesium powder as catalyst in the presence of ammonium chloride at room temperature in methanol leads to hydrazo compounds.

Pyridazinedione derivatives useful in treatment of neurological disorders

The present invention relates to pyridazino[4,5-b]indoles, and pharmaceutically useful salts thereof, which are excitatory amino acid antagonists and which are useful when such antagonism is desired such as in the treatment of neurological disorders. The invention further provides pharmaceutical compositions containing pyridazino[4,5-b]indoles as active ingredient, and methods for the treatment of neurological disorders.

Synthesis of Substituted Dibenzophospholes. Part 1.

Approaches to the synthesis of 4,6-diaryl-5-hydroxydibenzophosphole 5-oxides are described. 3,5,7-Trihydroxydibenzophosphole 5-oxide and several of its O-substituted derivarives were made either from 5-hydroxydibenzophosphole 5-oxide (convenient preparation described) by dinitration, reduction and tetrazotization or from 2,2'-dibromo-4,4'-dimethoxybiphenyl via lithiation and reaction with dichloromorpholinophosphine with subsequent oxidation. 3,5,7-Trihydroxydibenzophosphole 5-oxide could be selectively blocked in the 2,8-positions by methyl groups generated via a Mannich reaction.The bis-2-iodobenzyl ethers of 3,7-dihydroxy-5-methoxydibenzophosphole 5-oxide and of its 2,8-dimethyl derivative were cyclized by photolysis to form 4,6-diaryl derivatives in poor yield.