55149-78-5

Basic information

• Product Name: Benzaldehyde, 3,4,5-trimethoxy-2-nitro-
• CAS NO: 55149-78-5
• Molecular Formula: C10H11NO6
• Molecular Weight: 241.2
• Mol File: 55149-78-5.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Benzaldehyde, 3,4,5-trimethoxy-2-nitro-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzaldehyde, 3,4,5-trimethoxy-2-nitro-(55149-78-5)
• EPA Substance Registry System: Benzaldehyde, 3,4,5-trimethoxy-2-nitro-(55149-78-5)

Safety Data

• Hazardous Substances Data: 55149-78-5(Hazardous Substances Data)

Upstream product

• 5081-42-5 3,4,5-trimethoxy-2-nitrobenzoic acid methyl ester 
• 5435-28-9 (3,4,5-trimethoxy-2-nitrophenyl)methanol 
• 86-81-7 3,4,5-trimethoxy-benzaldehyde 
• 66907-52-6 3,4,5-trimethoxy-2-nitrobenzoic acid 
• 7664-93-9 sulfuric acid 
• 7697-37-2 nitric acid 

Downstream Products

• 132256-98-5 1,2,3-trimethoxy-4-nitro-5-(2-nitrovinyl)benzene 
• 1308881-77-7 1-(4'-methylbenzyl)-5,6,7-trimethoxyindole 
• 1308881-82-4 1-(3'-fluoro-4'-methoxybenzyl)-5,6,7-trimethoxy-1H-indole 
• 1308881-62-0 2-methoxy-5-(5,6,7-trimethoxyindol-1-yl)phenol 
• 1379535-26-8 1-(3,4,5-trimethoxy-2-nitrophenyl)prop-2-yn-1-ol 
• 1379535-66-6 (Z)-3-(4-methoxyphenylamino)-1-(3,4,5-trimethoxy-2-nitrophenyl)prop-2-en-1-one 
• 1379535-30-4 1-(3,4,5-trimethoxy-2-nitrophenyl)prop-2-yn-1-one 
• 1276042-97-7 (2-amino-3,4,5-trimethoxyphenyl)(3-fluoro-4-methoxyphenyl)methanone 
• 1276042-93-3 (2-amino-3,4,5-trimethoxyphenyl)(4-(dimethylamino)phenyl)methanone 
• 1276042-94-4 (2-amino-3,4,5-trimethoxyphenyl)(4-fluorophenyl)methanone 
• 1276042-91-1 (2-amino-3,4,5-trimethoxyphenyl)(p-tolyl)methanone 
• 1276043-03-8 C₁₇H₁₇NO₇ 

Relevant articles and documents

Synthesis and Evaluation of a New Series of 8-(2-Nitroaryl)Xanthines as Adenosine Receptor Ligands

(Table presented.). A new series of 1,3-dimethylxanthine derivatives bearing 8-(2-nitroaryl) residue was synthesized and evaluated for affinity for recombinant human adenosine receptors subtypes. Nitrate esters of 7-substituted-1,3-dimethyl-8-phenylxanthines were also synthesized and tested. Introducing a nitro substituent at the 2-position of the 8-substituted phenyl ring resulted in generally low affinity for adenosine receptors (ARs), selectivity toward the A2A subtype was enhanced in some of the compounds. 8-(4-Cyclopentyloxy-5-methoxy-2-nitrophenyl)-1,3-dimethylxanthine (9e) proved to be a potent compound among the 2-nitrophenyl substituted xanthines exhibiting a Ki = 1 μM at human A2A ARs with at least 30 fold selectivity versus human A1 and A2B ARs. Replacement of 8-chloropropoxy phenyl with 8-nitrooxypropoxy phenyl resulted in a negligible change in binding affinity of the 8-substituted xanthines for various AR subtypes. Drug Dev Res 77 : 241–250, 2016.

Concise syntheses of N-aryl-5,6,7-trimethoxyindoles as antimitotic and vascular disrupting agents: Application of the copper-mediated Ullmann-type arylation

In an attempt to mimic the 3,4,5-trimethoxyphenyl-Z-stilbene moiety of combretastatin A-4, a series of N-aryl-5,6,7-trimethoxyindoles were synthesized via copper-catalyzed Ullmann-type N-arylation through the corresponding 5,6,7-trimethoxyindole and aryl halides. These synthesized compounds demonstrated potent antiproliferative activity providing a novel skeleton for potent tubulin polymerization inhibitors.

2-Amino and 2′-aminocombretastatin derivatives as potent antimitotic agents

A novel series of 2-amino and 2′-aminocombretastatin derivatives were synthesized and evaluated for antitumor activity. Several compounds had excellent antiproliferative activity as inhibitors of tubulin polymerization. Compounds 11, 20, and 21 with ICsu