55159-77-8

Basic information

• Product Name: 3,4-diphenyl-5-[1-phenylmeth-(Z)-ylidene]-1,5-dihydropyrrol-2-one
• Synonyms: 3,4-diphenyl-5-[1-phenylmeth-(Z)-ylidene]-1,5-dihydropyrrol-2-one
• CAS NO: 55159-77-8
• Molecular Weight: 323.394
• Mol File: 55159-77-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 3,4-diphenyl-5-[1-phenylmeth-(Z)-ylidene]-1,5-dihydropyrrol-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4-diphenyl-5-[1-phenylmeth-(Z)-ylidene]-1,5-dihydropyrrol-2-one(55159-77-8)
• EPA Substance Registry System: 3,4-diphenyl-5-[1-phenylmeth-(Z)-ylidene]-1,5-dihydropyrrol-2-one(55159-77-8)

Safety Data

• Hazardous Substances Data: 55159-77-8(Hazardous Substances Data)

Upstream product

• 14072-62-9 N-(2-phenylacetyl)benzamide 
• 100-52-7 benzaldehyde 
• 1202075-98-6 1-acetyl-3,4-diphenyl-1,5-dihydropyrrol-2-one 
• 102-04-5 1,3-Diphenylpropanone 
• 95956-55-1 erythro-5-Oxo-2,3,5-triphenylpentansaeure-methylester 
• 53343-91-2 (+/-)-erythro-5-oxo-2.3.5-triphenyl-valeric acid 
• 6322-80-1 5-benzoyl-3,4-diphenyl-dihydro-furan-2-one 
• 95956-55-1 2,3,5-triphenyl-δ-carbonylvalerate methyl ester 
• 1603-79-8 phenylglyoxylic acid ethyl ester 
• 64-17-5 ethanol 
• 3457-83-8 2,4,5-triphenyl-cyclopent-4-ene-1,3-dione 

Relevant articles and documents

Evaluation of pyrrolin-2-one derivatives synthesized by a new practical method as inhibitors of plasminogen activator inhibitor-1 (PAI-1)

We describe in this Letter a new synthetic method for pyrrolin-2-ones as potent plasminogen activator inhibitor-1 (PAI-1) inhibitors. Pyrrolin-2-one derivatives synthesized from N-2-oxoethylamides and aldehydes in aqueous NaOH by one-pot were evaluated for their PAI-1 inhibitory activity. Among these derivatives, compounds 16 and 18 were found to possess potent PAI-1 inhibitory activity (compound 16: IC50: 0.69 μM, compound 18: IC50: 0.65 μM).