55168-33-7

Upstream product

• 64-19-7 acetic acid 
• 1131-60-8 p-cyclohexylphenol 
• 108-24-7 acetic anhydride 

Downstream Products

• 73051-18-0 (2S,4R)-6-Cyclohexyl-4-methyl-4-phenyl-4H-benzo[1,3]dioxine-2-carboxylic acid 
• 73051-18-0 (2R,4R)-6-Cyclohexyl-4-methyl-4-phenyl-4H-benzo[1,3]dioxine-2-carboxylic acid 
• 73051-20-4 (2R,4R)-6-Cyclohexyl-4-methyl-4-phenyl-4H-benzo[1,3]dioxine-2-carboxylic acid methyl ester 
• 86609-02-1 5-cyclohexyl-2-hydroxy-α-methyl-α-phenyl-benzene-methanol 

Relevant academic research and scientific papers

[4H]-1,3-Benzodioxin-2-carboxylic acids

Novel racemates and optically active isomers and mixtures of isomers of [4H]-1,3-benzodioxin-2-carboxylic acid compounds of the formula STR1 wherein R1 is selected from the group consisting of hydrogen, alkyl of 1 to 5 carbon atoms, dialkylamino alkyl with alkyls of 1 to 5 carbon atoms, alkali metal, alkaline earth metal, aluminum, --NH4, non-toxic pharmaceutically acceptable amines, 2,3-dihydroxypropanyl and (2,2-dimethyl-1,3-dioxolan-4-yl)-methyl, R2 is selected from the group consisting of hydrogen and alkyl of 1 to 5 carbon atoms, R3 and R6 are individually selected from the group consisting of hydrogen, alkyl of 1 to 6 carbon atoms, ethenyl and cyclohexyl and taken together with the carbon atom to which they are attached form cyclohexyl, R5 is selected from the group consisting of hydrogen and halogen or R1 and R2 have the above definitions, R6 is STR2 R4 and R5 are individually selected from the group consisting of hydrogen, halogen, --CF3, cyclohexyl, alkoxy of 1 to 3 carbon atoms, alkyl of 1 to 3 carbon atoms and p-chlorophenoxy and R3 is selected from the group consisting of 2-propenyl, ethenyl, cyclohexyl, benzyl, hydrogen and alkyl of 1 to 5 carbon atoms with the proviso that when R3 is alkyl, at least one of R4 and R5 is no hydrogen or halogen and when R3 is hydrogen, at least one of R4 and R5 is not hydrogen, halogen or --CF3 and the non-toxic, pharmaceutically acceptable acid addition salts thereof when R1 is dialkylaminoalkyl which have a marked hypolipemiant activity and reduces the plasmatic level of lipids, triglycerides and cholestrol and their preparation.

Aurone derivatives

Substituted aurones of formula (I): STR1 wherein R1, R2, R3, R4, R5 and R6 are the same or different and can each represent hydrogen, halogen, C1-6 alkyl, C1-6 alkoxy, C3-8 cycloalkyl, optionally substituted phenyl, C1-6 haloalkyl, amido, amino, cyano, hydroxy, nitro, C2-4 alkenyl, carboxyl, tetrazol-5-yl and --CH=CHCOOH; or wherein R1 and R2 taken together can represent a group of formula --CH=CH--CH=CH-- provided that at least one of R1, R2, R3, R4, R5 and R6 is carboxyl, tetrazol-5-yl or --CH=CHCOOH; or a pharmaceutically-acceptable salt or ester thereof, are effective in the prophylactic chemotherapy of allergic conditions such as bronchial asthma.