55182-40-6Relevant academic research and scientific papers
(3+2) Cycloadditions of Thiouronium Ylides: A Room-Temperature, One-Pot Approach to Dihydrothiophenes
Neuhaus, James D.,Angyal, Peter,Oost, Rik,Maulide, Nuno
, p. 2479 - 2485 (2018)
A room-temperature (3+2) cycloaddition sequence for the synthesis of highly substituted dihydrothiophene derivatives has been developed. By utilizing structurally unique thiocarbonyl ylides, the reactivity of these traditionally high-energy intermediates can be modulated, enabling a synthetically useful transformation to proceed under mild conditions.
