5519-69-7

Upstream product

• 3392-12-9 Boc-Val-ONSu 
• 80944-66-7 Boc-D-Phe-Pro-OEt 
• 77511-33-2 N-tert-butoxycarbonyl-D-phenylalanine tetrabutylammonium salt 
• 16652-71-4 benzyl (2S)-2-pyrrolidinecarboxylate hydrochloride 
• 18942-49-9 Boc-D-Phe-OH 
• 2480-93-5 Boc-Orn(Z)-OH 
• 13139-15-6 N-tert-butoxycarbonyl-L-leucine 
• 13734-41-3 t-Boc-L-valine 
• 74863-01-7 Boc-Val-Orn(Z)-Leu-D-Phe-Pro-OBzl 
• 16942-40-8 H-D-Phe-Pro-OEt*HCl 
• 96099-83-1 Orn(Z)-Leu-D-Phe-Pro-OBzl*HCl 
• 96099-73-9 boc-Orn(Z)-Leu-D-Phe-Pro-OBzl 
• 5519-68-6 Boc-Val-Orn(Z)-Leu-D-Phe-Pro-OEt 

Downstream Products

• 57471-76-8 ((S)-4-((S)-2-Amino-3-methyl-butyrylamino)-4-{(S)-1-[(R)-1-benzyl-2-((S)-2-hydrazinocarbonyl-pyrrolidin-1-yl)-2-oxo-ethylcarbamoyl]-3-methyl-butylcarbamoyl}-butyl)-carbamic acid benzyl ester; hydrochloride 
• 5519-70-0 HCl*H-Val-Orn(Z)-Leu-D-Phe-Pro-OH 

Relevant academic research and scientific papers

ONE-POT CYCLIZATION OF A PEPTIDE BY THE USE OF (5-NITROPYRIDYL)DIPHENYL PHOSPHINATE: THE SYNTHESIS OF CYCLIC DECAPEPTIDE GRAMICIDIN S

One-pot synthesis of gramicidin S, cyclic decapeptide, was successfully achieved by treatment of the corresponding linear decapeptide with (5-nitropyridyl)diphenyl phosphinate, a new condensing reagent, in pyridine.Similarly, the phosphinic ester can be successfully employed in the Young test as well as syntheses of dipeptides.

FACILE SYNTHESIS OF GRAMICIDIN S VIA CYCLIZATION OF A LINEAR PENTAPEPTIDE

Azide and N-hydroxysuccinimide ester of five pentapeptides related to gramicidin S (cyclic decapeptide) were cyclized to determine the ratio of dimer to monomer in the cyclization product, the pentapeptide dervative with D-Phe as C-terminus giving the dimer in good yield.