551935-98-9Relevant academic research and scientific papers
3,5-Disubstituted-[1,2,4]-oxadiazoles and analogs as activators of caspases and inducers of apoptosis and the use thereof
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, (2008/06/13)
Disclosed are 3,5-disubstituted-[1,2,4]-oxadiazoles and analogs thereof, represented by the Formula I: wherein Ar1, R2, A, B and D are defined herein. The present invention relates to the discovery that compounds having Formula I are activators of caspases and inducers of apoptosis. Therefore, the activators of caspases and inducers of apoptosis of this invention may be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.
Novel Fused N-Heterocycles Derived from 3,6-Dichloro-4-pyridazinecarbonyl Chloride
Ried, Walter,Eichhorn, Thomas A.
, p. 2049 - 2052 (2007/10/02)
3,6-Dichloro-4-pyridazinecarbonyl chloride (4) reacts with primary amines to yield the N-containing fused heterocyclic compounds 2, 8, and 9a, b. 4 forms the pyridazino-oxadiazepines 7a-d with the in situ generated hydroxyguanidines 6a-d.The diazocinedione 1 is obtained by reaction of 3,6-dichloro-4-pyridazinecarboxamide (3) with anthranilic acid methyl ester.
