1530-88-7

Basic information

• Product Name: 1-Cyanopyrrolidine
• Synonyms: 1-CYANOPYRROLIDINE;N-CYANOPYRROLIDINE;PYRROLIDINE-1-CARBONITRILE;PYRROLIDINOCYANAMIDE;PYRROLIDINO-N-CARBONITRILE;Tetramethylenecyanamide;1-Pyrrolidinecarbonitrile;N-CYANPYRROLIDIN 97%
• CAS NO: 1530-88-7
• Molecular Formula: C₅H₈N₂
• Molecular Weight: 96.13
• EINECS: 216-234-3
• Product Categories: Imidazoles, Pyrroles, Pyrazoles, Pyrrolidines;Pyrrole&Pyrrolidine&Pyrroline
• Mol File: 1530-88-7.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 75-77 °C1.8 mm Hg(lit.)
• Flash Point: 225 °F
• Appearance: /
• Density: 0.954 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.0498mmHg at 25°C
• Refractive Index: n20/D 1.469(lit.)
• PKA: -4.27±0.20(Predicted)
• CAS DataBase Reference: 1-Cyanopyrrolidine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Cyanopyrrolidine(1530-88-7)
• EPA Substance Registry System: 1-Cyanopyrrolidine(1530-88-7)

Safety Data

• Hazard Codes: Xn
• Statements: 20/21/22
• Safety Statements: 36
• RIDADR: 3276
• WGK Germany: 3
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 1530-88-7(Hazardous Substances Data)

Usage

General Description

1-Cyanopyrrolidine is a chemical compound with the molecular formula C6H8N2. It is a colorless to pale yellow liquid with a faint odor and is mainly used in the pharmaceutical industry as a building block for the synthesis of various pharmaceutical compounds. 1-Cyanopyrrolidine is also used in the production of agricultural chemicals and as an intermediate in the manufacture of specialty chemicals. It is considered to be a hazardous chemical and is known to cause irritation to the skin and eyes upon direct contact. The compound is also flammable and should be handled with caution.

InChI:InChI=1/C5H8N2/c6-5-7-3-1-2-4-7/h1-4H2

Upstream product

• 4736-71-4 N-pyrrolidinecarboxamide 
• 123-75-1 pyrrolidine 
• 151-50-8 potassium cyanide 
• 1271-28-9 nickelocene 
• 172876-96-9 3-oxo-1λ³-benzo[d][1,2]iodaoxole-1(3H)-carbonitrile 
• 7677-24-9 trimethylsilyl cyanide 
• 24420-11-9 1-allyl-pyrrolidine 
• 506-68-3 bromocyane 
• 72139-73-2 2,2,2-trichloro-1-(pyrrolidin-1-yl)ethanimine 
• 5564-73-8 1-(dimethoxymethyl)pyrrolidine 
• 89026-70-0 N(pyrrolidinomethyliden)harnstoff 
• 64965-62-4 N,N-Tetramethylen-N'-cyanformamidin 

Downstream Products

• 6280-30-4 5-(1-pyrrolidinyl)-1H-1,2,3,4-tetrazole 
• 58415-24-0 4-methyl-N-(pyrrolidin-1-ylmethylene)benzamide 
• 16268-87-4 4,6-di-pyrrolidin-1-yl-[1,3,5]triazin-2-ylamine 
• 5794-91-2 2,4,6-tri(pyrrolidin-1-yl)-1,3,5-triazine 

Relevant articles and documents

Isoform-selective substrates of nitric oxide synthase

Because of the double-edged nature of NO, the development of isoform-selective NOS substrates is a highly desirable goal. Given the striking similarity in the heme active sites of the three NOS isoforms, it presents an challenging problem. Several N-aryl-N′-hydroxyguanidines have recently been shown as substrates that are selective for iNOS over nNOS. Here, we report the first success that 3 is a good substrate for nNOS (70% activity of NOHA, Km ≈ 40 ± 6 μM) over iNOS.

Synthesis method of cyanamide

The invention relates to the field of synthesis of chemical products, in particular to a synthesis method of a cyanamide compound. According to the method, cyanamide is efficiently synthesized under the conditions of air and room temperature by starting from easily available secondary amine compounds, taking cheap and green TMSCN as a cyanide source and adopting green and pollution-free current as a reaction driving agent. Compared with a conventional cyanamide synthesis method, the method disclosed by the invention has the obvious advantages of cheap and easily available reaction raw materials, minimum environmental pollution caused by current, good tolerance to various functional groups on aromatic rings and alicyclic rings, high yield and the like. The method disclosed by the invention can be widely applied to synthesis in the fields of medicines, materials, natural products and the like in industrial and academic circles.

Tris(3,5-dimethylpyrazolyl)methane copper(I) complexes featuring one disubstituted cyanamide ligand

The complexes [Cu{HC(3,5-Me2pz)3}(NCNR2)][BF4] (1–8; R2 = Me2 1, Et2 2, C5H10 3, C4H8O 4, C4H8 5, C3H