551944-25-3Relevant academic research and scientific papers
Discovery and development of dimeric podocarpic acid leads as potent agonists of liver X receptor with HDL cholesterol raising activity in mice and hamsters
Singh, Sheo B.,Ondeyka, John G.,Liu, Weiguo,Chen, Steve,Chen, Tom S.,Li, Xiaohua,Bouffard, Aileen,Dropinski, James,Jones, A. Brian,McCormick, Sherrie,Hayes, Nancy,Wang, Jianhua,Sharma, Neelam,MacNaul, Karen,Hernandez, Melba,Chao, Yu-Sheng,Baffic, Joanne,Lam, My-Hanh,Burton, Charlotte,Sparrow, Carl P.,Menke, John G.
, p. 2824 - 2828 (2007/10/03)
Liver X receptors are nuclear receptors that regulate metabolism of cholesterol. They are activated by oxysterols resulting in increased transcription of the ABCA1 gene, promoting cholesterol efflux and HDL formation. We have identified podocarpic acid an
Therapeutic compounds for treating dyslipidemic conditions
-
, (2008/06/13)
Compounds of Formula I and the pharmaceutically acceptable salts and esters thereof, wherein Z is selected from the group consisting of: (a) Formula Ia ?and (b) Formula Ib are novel LXR agonists and are useful in the treatment of dyslipidemic conditions p
