551958-89-5Relevant academic research and scientific papers
Method for producing optically active IHOG and monatin
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, (2008/06/13)
The present invention relates to a method for producing optically active IHOG, which can in turn be used for the production of monatin. The present invention further relates to a method for producing optically active monatin, and an aldolase which can be used in these methods. As such, the present invention enables the synthesis of 4-(Indole-3-ylmethyl)-4-hydroxy-2-oxoglutaric acid with high optical purity, which is useful as an intermediate in the synthesis of optically active monatin, from indole pyruvic acid and pyruvic acid (or oxaloacetic acid).
Process of producing glutamate derivatives
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Page/Page column 42-43, (2008/06/13)
The present invention relates to a process for producing efficiently glutamic acid derivatives (including salts thereof) such as monatin by converting a substituted α-keto acid of formula (1) into a glutamic acid derivative of formula (2) in the presence of an enzyme catalyzing conversion of the same
Variant aldolase and processes for producing an optically active IHOG and an optically active monatin using the same
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, (2008/06/13)
The present invention relates to variant aldolase enzymes that are modified so as to produce IHOG, a process for producing an optically active IHOG using the same, and a process for producing an optically active monatin.
