55197-25-6

Basic information

• Product Name: (3-CYANOPHENOXY) ACETIC ACID ETHYL ESTER
• Synonyms: (3-CYANOPHENOXY) ACETIC ACID ETHYL ESTER;Ethyl 2-(3-Cyanophenoxy)acetate;2-(3-cyanophenoxy)Acetic acid ethyl ester
• CAS NO: 55197-25-6
• Molecular Formula: C₁₁H₁₁NO₃
• Molecular Weight: 205.21
• Mol File: 55197-25-6.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (3-CYANOPHENOXY) ACETIC ACID ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: (3-CYANOPHENOXY) ACETIC ACID ETHYL ESTER(55197-25-6)
• EPA Substance Registry System: (3-CYANOPHENOXY) ACETIC ACID ETHYL ESTER(55197-25-6)

Safety Data

• Hazardous Substances Data: 55197-25-6(Hazardous Substances Data)

Usage

General Description

(3-Cyanophenoxy) acetic acid ethyl ester is a chemical compound with the molecular formula C11H11NO3. It is a derivative of phenoxyacetic acid and contains a cyanide group. (3-CYANOPHENOXY) ACETIC ACID ETHYL ESTER is commonly used as a herbicide and a plant growth regulator. It works by interfering with the plant's growth hormones, leading to stunted growth and eventual death. It is primarily used in agricultural settings to control the growth of weeds and undesirable plants. Additionally, it can be used as a precursor in the synthesis of other organic compounds. However, it is important to use this compound with caution, as it can be harmful if ingested or inhaled and can cause skin and eye irritation.

Upstream product

• 873-62-1 m-cyanophenol 
• 105-36-2 ethyl bromoacetate 

Downstream Products

• 57928-93-5 3-[(2-hydroxyethyl)oxy]benzonitrile 
• 1879-58-9 2-(3-cyanophenoxy) acetic acid 
• 935759-22-1 5-methyl-4-oxo-N-[(3-{[2-(1H-1,2,4-triazol-3-yloxy)ethyl]-oxy}phenyl)methyl]-3,4-dihydro-thieno[2,3-d]pyrimidine-2-carboxamide 
• 935760-22-8 1-{3-[(2-{[1-(triphenylmethyl)-1H-1,2,4-triazol-3-yl]oxy}-ethyl)oxy]phenyl}methanamine 
• 935760-21-7 3-[(2-{[1-(triphenylmethyl)-1H-1,2,4-triazol-3-yl]oxy}ethyl)-oxy]benzonitrile 
• 935759-63-0 5-(4-methoxyphenyl)-4-oxo-N-{3-[2-(1H-1,2,4-triazol-3-yloxy)ethoxy]benzyl}-3,4-dihydro-thieno[2,3-d]pyrimidine-2-carboxamide 
• 935759-57-2 5-(3-methoxyphenyl)-4-oxo-N-{3-[2-(1H-1,2,4-triazol-3-yloxy)ethoxy]benzyl}-3,4-dihydro-thieno[2,3-d]pyrimidine-2-carboxamide 
• 935759-54-9 5-(2-methoxyphenyl)-4-oxo-N-{3-[2-(1H-1,2,4-triazol-3-yloxy)ethoxy]benzyl}-3,4-dihydro-thieno[2,3-d]pyrimidine-2-carboxamide 
• 935759-61-8 5-(4-chlorophenyl)-4-oxo-N-{3-[2-(1H-1,2,4-triazol-3-yloxy)-ethoxy]benzyl}-3,4-dihydro-thieno[2,3-d]pyrimidine-2-carboxamide 
• 935759-53-8 5-(2-chlorophenyl)-4-oxo-N-{3-[2-(1H-1,2,4-triazol-3-yloxy)-ethoxy]benzyl}-3,4-dihydro-thieno[2,3-d]pyrimidine-2-carboxamide 

Relevant articles and documents

A Comparative Assessment Study of Known Small-Molecule Keap1-Nrf2 Protein-Protein Interaction Inhibitors: Chemical Synthesis, Binding Properties, and Cellular Activity

Inhibiting the protein-protein interaction (PPI) between the transcription factor Nrf2 and its repressor protein Keap1 has emerged as a promising strategy to target oxidative stress in diseases, including central nervous system (CNS) disorders. Numerous non-covalent small-molecule Keap1-Nrf2 PPI inhibitors have been reported to date, but many feature suboptimal physicochemical properties for permeating the blood-brain barrier, while others contain problematic structural moieties. Here, we present the first side-by-side assessment of all reported Keap1-Nrf2 PPI inhibitor classes using fluorescence polarization, thermal shift assay, and surface plasmon resonance - and further evaluate the compounds in an NQO1 induction cell assay and in counter tests for nonspecific activities. Surprisingly, half of the compounds were inactive or deviated substantially from reported activities, while we confirm the cross-assay activities for others. Through this study, we have identified the most promising Keap1-Nrf2 inhibitors that can serve as pharmacological probes or starting points for developing CNS-active Keap1 inhibitors.

HETEROCYCLIC AMIDE COMPOUND AND USE THEREOF

The present invention provides a novel amide compound represented by the following formula, which has a matrix metalloproteinase inhibitory activity and is useful as a pharmaceutical agent. wherein each symbol is as defined in the specification.