55197-32-5

Usage

Uses

Used in Pharmaceutical Industry:
(4-Cyano-2-nitro-phenoxy)-acetic acid ethyl ester is used as an intermediate in the synthesis of various pharmaceutical compounds. Its unique structure allows for the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical industry, (4-Cyano-2-nitro-phenoxy)-acetic acid ethyl ester is used as a key component in the production of herbicides and fungicides. Its chemical properties enable the creation of effective agents for controlling weeds and fungi in agricultural settings.
Used in Specialty Chemicals:
(4-Cyano-2-nitro-phenoxy)-acetic acid ethyl ester is also utilized in the synthesis of specialty chemicals, where its versatility and reactivity contribute to the development of innovative products for various applications.

Upstream product

• 3272-08-0 4-hydroxy-3-nitrobenzonitrile 
• 105-36-2 ethyl bromoacetate 

Downstream Products

• 134997-74-3 3-oxo-3,4-dihydro-2H-benzo[1,4]oxazine-6-carbonitrile 

Relevant academic research and scientific papers

Novel heteroaryl substituted piperidine derivatives which are L-CPT1 inhibitors

The invention is concerned with novel substituted piperidine derivatives of formula (I) wherein R1, R2, R3, R4, R5, R6, R7 and X are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds inhibit L-CPT1 and can be used as medicaments.

Synthesis of isosteres of p-amidinophenylpyruvic acid. Inhibitors of trypsin thrombin, and pancreatic kallikrein.

A series of amino acids, amidino acids, and amidino esters was synthesized and the compounds were evaluated for their inhibitory activity against bovine trypsin, bovine thrombin, and porcine pancreatic kallikrein and as anticoagulants. Among these compounds, ethyl 4-amidino-2-iodophenoxyacetate was found to be the most effective inhibitor of the enzymes in question, with a potency (Ki = 3.16 x 10-6 M vs. trypsin; Ki = 4.8 x 10-5 M vs. thrombin) similar to that of p-amidinophenylpyruvic acid (Ki = 6.0 x 10-6 M vs. trypsin; Ki = 2.0 x 10-5 M vs. thrombin). Ethyl 4-amidino-2-iodophenoxyacetate was also found to be the most effective in blocking the clotting activity of plasma, as indicated by significant prolongation of the partial thromboplastin time. This paper reports the synthetic methods, the enzyme inhibitory activity, and the structure-activity relationships observed.