5520-63-8Relevant academic research and scientific papers
Investigations into the parallel synthesis of novel pyrrole-oxazole analogues of the insecticide pirate
Loughlin, Wendy A.,Henderson, Luke C.,Elson, Kathryn E.,Murphy, Michelle E.
, p. 1975 - 1980 (2007/10/03)
Investigations into the parallel synthesis of selected analogues of a structurally unique pyrrole-oxazole analogue of the pyrrole insecticide pirate, are reported. Acylaminoketone salts were obtained from ketobromides in moderate to high yields and excell
SYNTHESIS OF LUMINOPHORIC DERIVATIVES OF PBD BASED ON 2,5-DIARYL SUBSTITUTED THIAZOLES AND OXAZOLES
Lhotak, Pavel,Kurfuerst, Antonin
, p. 2720 - 2728 (2007/10/02)
The Friedel-Crafts acylation of 2-(biphenyl-4-yl)-5-phenyl-1,3,4-oxadiazole (PBD) with hippuryl chloride has been used to prepare the derivative V which on cyclization with POCl3 or P4S10 gives the respective oxazole (or thiazole) derivative of PBD, XIa or XIb.The reaction of carboxylic acid II with 4-(ω-aminoacetyl)biphenyl in the presence of CDI gives N-acyl-α-aminoketone VII; the analogous compound VI has been prepared by acylating ω-aminoacetophenone with acyl chloride III.The cyclization of these compounds gives bifluorophores Xa - Xd.
New biphenyl derivatives II: 1-(4-biphenylyl)-1-hydroxy-2-aminoethanes and 1-(4-biphenylyl)-1-chloro-2-aminoethanes as potential β-adrenoceptor blocking agents
Shafik,Askar
, p. 776 - 780 (2007/10/05)
Series of 1-(4-biphenylyl)-1-hydroxy-2-aminoethanes and 1-(4-biphenylyl)-1-chloro-2-aminoethanes were synthesized. Newly developed reaction conditions for aryl aminomethyl ketone reduction and reductive alkylation, using sodium borhydride, are described. The prepared compounds were examined for adrenergic blocking activity on an anesthetized dog blood pressure preparation and on isolated toad hearts. β-adrenergic blockade was investigated using isoproterenol as the agonist. The benzylamino and cyclohexylamino analogs exhibited marked β-adrenoceptor blocking activity, for which the latter derivatives were more potent.
