55204-36-9

Upstream product

• 446-96-8 N-ethyl-2,2,2-trifluoro-N-phenylacetamide 
• 103-69-5 N-ethyl-N-phenylamine 
• 76-05-1 trifluoroacetic acid 
• 62-53-3 aniline 
• 155094-66-9 2-Chloro-N-ethyl-2-fluoro-N-phenyl-acetamide 
• 155094-50-1 N-(2-Chloro-2-fluoroethyl)-N-ethylaniline 
• 54962-15-1 lithium N-ethyl-N-phenylamide 

Downstream Products

• 110972-16-2 N-Ethyl-N-(1-methoxy-2,2,2-trifluoroethyl)aniline 
• 110972-20-8 N-(1-cyano-2,2,2-trifluoroethyl)-N-ethylaniline 
• 126422-72-8 4-cyano-N-ethyl-N-(2,2,2-trifluoroethyl)aniline 
• 126422-73-9 N-(1-cyanoethyl)-N-(2,2,2-trifluoroethyl)aniline 
• 126422-71-7 2-cyano-N-ethyl-N-(2,2,2-trifluoroethyl)aniline 

Relevant academic research and scientific papers

Direct N-Alkylation/Fluoroalkylation of Amines Using Carboxylic Acids via Transition-Metal-Free Catalysis

A scalable protocol of direct N-mono/di-alkyl/fluoroalkylation of primary/secondary amines has been constructed with various carboxylic acids as coupling agents under the catalysis of a simple air-tolerant inorganic salt, K3PO4. Advantageous features include 100 examples, 10 drugs and drug-like amines, fluorinated complex tertiary amines, gram-scale synthesis and isotope-labelling amine, thus demonstrating the potential applicability in industry of this methodology. The involvement of relatively less reactive silicon-hydride compared with the traditional reactive metal-hydride or boron-hydride species required to reduce the amide intermediates presumably contributes to the remarkable functional group compatibility. (Figure presented.).

Electrolytic Reactions of Fluoroorganic Compounds. 14. Regioselective Anodic Methoxylation of N-(Fluoroethyl)amines. Preparation of Highly Useful Fluoroalkylated Building Blocks

Anodic methoxylation of various types of N-(fluoroethyl)amines, ArRNCH2Rf (Rf = CF3, CHF2, CH2F, etc.) has been systematically studied and it was found that a methoxy group was exclusively or preferentially introduced into the position α to the fluoromethyl (Rf) group, depending on the Rf and R groups.The effect of the Rf group on the promotion of the anodic α-methoxylation decreased in the order CF3, CHF2, and CH2F.This remarkable promotion effect and unique regioselectivity can be explained mainly in terms of the α-CH kinetic acidities of the cation radicals formed by one-electron oxidation of the amines.The α-methoxylated products are highly useful precursors for the construction of carbon-carbon bonds α to the trifluoromethyl and difluoromethyl groups, which is difficult by other methods.

Fluoroalkylaryliodonuim compounds

Fluoroalkylaryliodonium compounds having the formula (I): STR1 wherein AR, A and Rf are as defined above, are disclosed. The fluoroalkylaryliodonium compounds of the present invention are useful as intermediates for producing N-fluoroalkylanilines or deri

Electrolytic Transformation of Fluoroorganic Compounds. 3. Highly Regioselective Anodic Methoxylation of N-(2,2,2-trifluoroethyl)amines

Anodic methoxylation of N-alkyl-N-(2,2,2-trifluoroethyl)anilines and N-(2,2,2-trifluoroethyl)diphenylamine places the methoxy group in the α-position (toward the trifluoromethyl group); these products are useful building blocks for the construction of a c

Process for dyeing synthetic fibers formed from aromatic polyesters and new monoazo dyestuffs useful for such dyeing

The dyeing of synthetic polyester fibers wherein the dyestuff is a mono-azo dyestuff of the formula STR1 in which X represents a hydrogen, chlorine, bromine, cyano, nitro or lower alkylsulphonyl radical, R1 represents hydrogen, chlorine or bromine atom or a lower alkyl, lower alkoxy or acylamino radical, R2 represents a hydrogen atom or a lower alkoxy radical and R3 represents a lower alkyl, β -hydroxyethyl, β-cyanoethyl, β-acetoxyethyl or β-(β-acetoxyethoxy)-ethyl group.