110972-16-2

Upstream product

• 67-56-1 methanol 
• 55204-36-9 N-ethyl-N-(2,2,2-trifluoro-ethyl)-aniline 
• 103-69-5 N-ethyl-N-phenylamine 
• 155094-66-9 2-Chloro-N-ethyl-2-fluoro-N-phenyl-acetamide 
• 155094-50-1 N-(2-Chloro-2-fluoroethyl)-N-ethylaniline 
• 54962-15-1 lithium N-ethyl-N-phenylamide 
• 446-96-8 N-ethyl-2,2,2-trifluoro-N-phenylacetamide 

Downstream Products

• 110972-20-8 N-(1-cyano-2,2,2-trifluoroethyl)-N-ethylaniline 

Relevant academic research and scientific papers

Electrolytic Transformation of Fluoroorganic Compounds. 3. Highly Regioselective Anodic Methoxylation of N-(2,2,2-trifluoroethyl)amines

Anodic methoxylation of N-alkyl-N-(2,2,2-trifluoroethyl)anilines and N-(2,2,2-trifluoroethyl)diphenylamine places the methoxy group in the α-position (toward the trifluoromethyl group); these products are useful building blocks for the construction of a c

Electrolytic Reactions of Fluoroorganic Compounds. 14. Regioselective Anodic Methoxylation of N-(Fluoroethyl)amines. Preparation of Highly Useful Fluoroalkylated Building Blocks

Anodic methoxylation of various types of N-(fluoroethyl)amines, ArRNCH2Rf (Rf = CF3, CHF2, CH2F, etc.) has been systematically studied and it was found that a methoxy group was exclusively or preferentially introduced into the position α to the fluoromethyl (Rf) group, depending on the Rf and R groups.The effect of the Rf group on the promotion of the anodic α-methoxylation decreased in the order CF3, CHF2, and CH2F.This remarkable promotion effect and unique regioselectivity can be explained mainly in terms of the α-CH kinetic acidities of the cation radicals formed by one-electron oxidation of the amines.The α-methoxylated products are highly useful precursors for the construction of carbon-carbon bonds α to the trifluoromethyl and difluoromethyl groups, which is difficult by other methods.