55210-79-2Relevant academic research and scientific papers
An efficient transformation of primary halides into nitriles through palladium-catalyzed hydrogen transfer reaction
Zou, Tao,Yu, Xiaoqiang,Feng, Xiujuan,Bao, Ming
, p. 10714 - 10717 (2015)
Two-step one-pot transformation of primary halides into corresponding nitriles is successfully achieved. Nucleophilic substitution of primary halides with sodium azide and subsequent palladium-catalyzed hydrogen transfer proceeds smoothly in the presence of sterically bulky ligand dicyclohexyl(2′,4′,6′-triisopropylbiphenyl-2-yl)phosphine (XPhos) in acetone to produce nitriles in satisfactory to good yields. This journal is
Palladium-Catalyzed Intermolecular Oxidative Diazidation of Alkenes
Peng, Haihui,Yuan, Zheliang,Chen, Pinhong,Liu, Guosheng
supporting information, p. 876 - 880 (2017/06/27)
A palladium-catalyzed oxidative vicinal diazidation of alkenes has been developed, in which TMSN3 was used as azide source. Both styrenes and unactivated alkenes are suitable for this reaction. And trans-alkyldiazides were obtained as major products from cyclic alkenes with moderate to good diastereoselectivities. This reaction afforded an efficient way for the synthesis of useful 1,2-diamines after hydrogenation.
