55212-79-8

Upstream product

• 123-75-1 pyrrolidine 
• 105-45-3 acetoacetic acid methyl ester 
• 5469-24-9 methyl 2,3-dibromobutyrate 
• 92234-51-0 methyl β-(1-imidazolyl)crotonoate 
• 91164-90-8 3-((Z)-2-Methoxycarbonyl-1-methyl-vinyl)-1-methyl-3H-imidazol-1-ium; iodide 

Downstream Products

• 30736-25-5 (3E)-5-((Ξ)-5-oxo-2-phenyl-oxazol-4-ylidene)-3-pyrrolidin-1-yl-pent-3-enoic acid methyl ester 
• 96722-36-0 2,4-Dimethyl-6-pyrrolidinobenzoeseure-methylester 
• 74105-96-7 2-Hydroxy-4-methyl-6-pyrrolidinobenzoesaeure-methylester 
• 1357268-73-5 methyl 4,4-difluoro-3-methyl-4-(phenylsulfonyl)-3-(pyrrolidin)-1-ylbutanoate 
• 87565-77-3 methyl 2-methyl-4-pyrrolidino-6-hydroxybenzoate 
• 33598-27-5 (+/-)-3-(1-pyrrolidinyl)butyric acid methyl ester 
• 105-25-9 1-(2-buten-1-yl)pyrrolidine 
• 116431-49-3 3-Oxo-2-((2R,3S,4R,5R,6R)-3,4,5-tris-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yl)-butyric acid methyl ester 
• 24838-35-5 1,1'-biphenyl-3,5-diyl-bis-pyrrolidine 
• 117648-47-2 5-Benzyl-2,5-dihydro-4-pyrrolidino-2-thiophen 
• 83577-52-0 methyl 7-phenyl-3-pyrrolidinohepta-2E,4E,6E-trienoate 
• 83577-50-8 methyl 5-phenyl-3-pyrrolidinopenta-2E,4E-dienoate 
• 83577-57-5 4-pyrrolidino-6-phenyl-1,2-pyrone 

Relevant academic research and scientific papers

Reduction of carbonyl compounds using the carbonyl reductase of kluyveromyces marxianus

A compound represented by a genera formula (Ia) or (Ib) and a stereo-selective preparation method thereof using a carbonyl reductase which is separated from Kluyveromyces marxianus. The compound can be prepared by reduction of substituted β-keto ester and can be used as an intermediate in preparing β-lactam group antibiotics.

The Compounds Related to 3-(1-Imidazolyl)-2-alken-1-ones. Preparation and Reactions

Compounds related to 3-(1-imidazolyl)-2-alken-1-ones, 3-(1-imidazolyl)-2-alkenoic acid derivatives and 2-alken-1-ones having heterocycles on the C-3 carbon were prepared.The reaction of nucleophiles with these compounds was also discussed.

Self-condensation of (β-Alkoxycarbonylalkylidene)ammonium Salts

Iminium chlorides or trifluoroacetates of type 2, formed by protonation of β-(alkoxycarbonyl)-enamines 1, have been proved to undergo condensation to give derivatives of 4-alkyl-2-amino-6-hydroxybenzoic acid 6 via elimination of ammonium salt and alcohol.The structures of 6 had been established by spectroscopic data as well as by further reactions.The range of application of this condensation reaction has been studied and the mechanism is discussed.In the primary step presumably a nucleophilic attack on the alkoxycarbonyl group of the iminium salt 2 takes place by the enamine 1 present in the equilibrium.Analogous reactions are also found for homologues of the enamine 1 (e.g. 11, 13 and 17) to give the condensation products 12, 14, 15, and 20.