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Davercin, also known as Erythromycin Cyclocarbonate, is a first-generation semi-synthetic macrolide antibiotic derived from Erythromycin A. It is prepared by coupling the 11and 12-OH groups to form a cyclic carbonate, which enhances the stability and hydrophobicity of the macrocyclic structure. Davercin exhibits broad-spectrum activity against various Gram-positive and Gram-negative bacteria and has shown comparable or better in vitro potency, low host toxicity, and improved pharmacokinetics compared to erythromycin.

55224-05-0

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55224-05-0 Usage

Uses

Used in Pharmaceutical Industry:
Davercin is used as an antibiotic for treating a variety of urogenital bacterial infections. Its improved stability and hydrophobicity contribute to its effectiveness in combating bacterial infections.
Used in Antimicrobial Applications:
Davercin is used as an antimicrobial agent, targeting the 50S ribosomal subunit of bacteria to inhibit protein synthesis, thereby blocking the progression of nascent polypeptide chains. This action provides a broad-spectrum activity against various Gram-positive and Gram-negative bacteria, making it a valuable tool in the fight against bacterial infections.
Used in Research and Development:
Davercin's improved properties compared to erythromycin make it a useful compound for research and development in the field of antibiotic discovery and development, potentially leading to the creation of new, more effective antibiotics.

Check Digit Verification of cas no

The CAS Registry Mumber 55224-05-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,5,2,2 and 4 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 55224-05:
(7*5)+(6*5)+(5*2)+(4*2)+(3*4)+(2*0)+(1*5)=100
100 % 10 = 0
So 55224-05-0 is a valid CAS Registry Number.
InChI:InChI=1/C38H65NO14/c1-14-25-38(10)32(52-35(44)53-38)20(4)27(40)18(2)16-36(8,45)31(51-34-28(41)24(39(11)12)15-19(3)47-34)21(5)29(22(6)33(43)49-25)50-26-17-37(9,46-13)30(42)23(7)48-26/h18-26,28-32,34,41-42,45H,14-17H2,1-13H3/t18-,19-,20+,21+,22-,23+,24+,25-,26+,28-,29+,30+,31?,32-,34+,36-,37-,38-/m1/s1

55224-05-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name Davercin

1.2 Other means of identification

Product number -
Other names Erythromycin Cyclocarbonate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:55224-05-0 SDS

55224-05-0Downstream Products

55224-05-0Relevant articles and documents

C-4" POSITION SUBSTITUTED MACROLIDE DERIVATIVE

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Page/Page column 240, (2012/09/11)

A macrolide compound represented by the formula (I) effective against erythromycin resistant bacteria (for example, resistant pneumococci, streptococci and mycoplasmas).

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