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Intermediate of Rolapitant is a chemical compound that acts as a crucial intermediate in the synthesis of Rolapitant, a pharmaceutical substance utilized for the treatment of chemotherapy-induced nausea and vomiting. This intermediate plays a vital role in the manufacturing process, ensuring the production of high-quality Rolapitant for medical applications.

552293-34-2

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552293-34-2 Usage

Uses

Used in Pharmaceutical Industry:
Intermediate of Rolapitant is used as a key building block for the synthesis of Rolapitant, which is a medication aimed at treating chemotherapy-induced nausea and vomiting. Its role in the production process is essential for creating a high-quality end product that effectively alleviates these side effects for cancer patients undergoing chemotherapy.

Check Digit Verification of cas no

The CAS Registry Mumber 552293-34-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 5,5,2,2,9 and 3 respectively; the second part has 2 digits, 3 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 552293-34:
(8*5)+(7*5)+(6*2)+(5*2)+(4*9)+(3*3)+(2*3)+(1*4)=152
152 % 10 = 2
So 552293-34-2 is a valid CAS Registry Number.

552293-34-2Relevant academic research and scientific papers

And as the antagonist aminopyrrolidine deriv. NK1 aminopiperidine (by machine translation)

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, (2016/10/08)

A NK 1 antagonist having the formula (I), wherein Ar 1 and Ar 2 are optionally substituted phenyl or heteroaryl, X 1 is an ether, thio or imino linkage, R 4 and R 5 are not both H or alkyl, and the remaining variables are as defined in the specification, useful for treating a number of disorders, including emesis, depression, anxiety and cough. Pharmaceutical compositions. Methods of treatment and combinations with other agents are also disclosed.

Conformation of gem-disubstituted alkylarylpiperidines and their implication in design and synthesis of a conformationally-rigidified NK 1 antagonist

Xiao, Dong,Wang, Cheng,Tsui, Hon-Chung,Palani, Anandan,Aslanian, Robert,Buevich, Alexei V.

, p. 6199 - 6203 (2013/10/22)

Piperidines are ubiquitous in pharmaceuticals and bioactive natural products. Understanding the structural and functional properties of piperidines plays a key role in drug design and development. This Letter reported studies of conformation of a set of g

FUSED RING NK1 ANTAGONISTS

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Page/Page column 57, (2008/06/13)

A compound having the general structure shown in Formula (1) or pharmaceutically acceptable salts and/or solvates thereof are useful in treating diseases or conditions mediated by NK1 receptors, for example various physiological disorders, symptoms or dis

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