552293-34-2

Usage

Uses

Used in Pharmaceutical Industry:
Intermediate of Rolapitant is used as a key building block for the synthesis of Rolapitant, which is a medication aimed at treating chemotherapy-induced nausea and vomiting. Its role in the production process is essential for creating a high-quality end product that effectively alleviates these side effects for cancer patients undergoing chemotherapy.

Upstream product

• 530441-95-3 (R)-1-(1-(bromomethoxy)ethyl)-3,5-bis(trifluoromethyl)benzene 
• 530441-39-5 C₃₄H₂₉F₆NO₅ 

Downstream Products

• 867045-67-8 C₄₇H₅₀F₆N₂O₇ 
• 552293-37-5 C₃₀H₂₇F₆NO₄ 
• 552293-38-6 C₃₂H₂₉F₆N₃O₅ 

Relevant academic research and scientific papers

And as the antagonist aminopyrrolidine deriv. NK1 aminopiperidine (by machine translation)

A NK 1 antagonist having the formula (I), wherein Ar 1 and Ar 2 are optionally substituted phenyl or heteroaryl, X 1 is an ether, thio or imino linkage, R 4 and R 5 are not both H or alkyl, and the remaining variables are as defined in the specification, useful for treating a number of disorders, including emesis, depression, anxiety and cough. Pharmaceutical compositions. Methods of treatment and combinations with other agents are also disclosed.

Conformation of gem-disubstituted alkylarylpiperidines and their implication in design and synthesis of a conformationally-rigidified NK 1 antagonist

Piperidines are ubiquitous in pharmaceuticals and bioactive natural products. Understanding the structural and functional properties of piperidines plays a key role in drug design and development. This Letter reported studies of conformation of a set of g

FUSED RING NK1 ANTAGONISTS

A compound having the general structure shown in Formula (1) or pharmaceutically acceptable salts and/or solvates thereof are useful in treating diseases or conditions mediated by NK1 receptors, for example various physiological disorders, symptoms or dis