552298-25-6Relevant academic research and scientific papers
Synthetic studies on borrelidin: enantioselective synthesis of the C1-C12 fragment.
Vong, Binh G,Abraham, Sunny,Xiang, Alan X,Theodorakis, Emmanuel A
, p. 1617 - 1620 (2003)
[structure: see text] An efficient, enantioselective synthesis of the C1-C12 fragment 2 of borrelidin is presented. Construction of the "skipped" polymethylene chain of 2 was accomplished by iteration of Myers' alkylation, while formation of the C3 stereocenter was achieved by Roush's asymmetric allylboration methodology.
Diverted total synthesis of the baulamycins and analogues reveals an alternate mechanism of action
Steele, Andrew D.,Ernouf, Guillaume,Lee, Young Eun,Wuest, William M.
supporting information, p. 1126 - 1129 (2018/02/23)
The baulamycins were identified as in vitro siderophore biosynthesis inhibitors. Diverted total synthesis was used to construct the natural products and eight strategic analogues, three of which had improved inhibitory activity. Biological testing then revealed that membrane damage is the predominant mode of action in Staphylococcus aureus cells.
