882005-20-1

Upstream product

• 174627-70-4 (2R,4S,6S)-7-(benzyloxy)-2,4,6-trimethylheptan-1-ol 
• 100-39-0 benzyl bromide 
• 552298-25-6 ((((2S,4R)-5-iodo-2,4-dimethylpentyl)oxy)methyl)benzene 
• 169105-67-3 (2R,4S)-5-(benzyloxy)-2,4-dimethylpentan-1-ol 
• 730964-33-7 (2S,4R,6R)-7-[1-(tert-butyl)-1,1-dimethylsilyl]oxy-2,4,6-trimethylheptan-1-ol 
• 730964-37-1 (4R,6R)-7-tert-butyldimethylsilyloxy-4,6-dimethyl-1-heptene 
• 730964-32-6 (R)-tert-butyldimethyl((2-methylpent-4-en-1-yl)oxy)silane 
• 333354-15-7 ((((2S,4S,6R)-2,4,6-trimethyloct-7-en-1-yl)oxy)methyl)benzene 

Downstream Products

• 882005-07-4 ethyl (2E,4R,6S,8S)-9-benzyloxy-4,6,8-trimethyl-2-nonenoate 
• 156953-84-3 (3R,9S,11S,13R,14S,16S)-14-hydroxy-3-[(4-hydroxy-3-iodophenyl)methyl]-4,9,11,13-tetramethyl-16-(propan-2-yl)-1-oxa-4,7-diazacyclohexadecane-2,5,8-trione 
• 333354-19-1 (E)-(5S,6R,8R,10S)-11-Benzyloxy-5-hydroxy-2,6,8,10-tetramethyl-undec-2-enoic acid ethyl ester 
• 333354-21-5 (3S,5S,6R,8R,10S)-11-Benzyloxy-5-(tert-butyl-dimethyl-silanyloxy)-2,6,8,10-tetramethyl-undec-1-en-3-ol 
• 333354-20-4 {(2S,3S)-3-[(2S,3R,5R,7S)-8-Benzyloxy-2-(tert-butyl-dimethyl-silanyloxy)-3,5,7-trimethyl-octyl]-2-methyl-oxiranyl}-methanol 
• 333354-25-9 (3R,9S,11S,13R,14S,16S)-14-Hydroxy-3-(3-iodo-4-triisopropylsilanyloxy-benzyl)-16-isopropyl-4,9,11,13-tetramethyl-1-oxa-4,7-diaza-cyclohexadecane-2,5,8-trione 
• 333354-26-0 Trifluoro-acetic acid (3R,9S,11S,13R,14S,16S)-3-(3-iodo-4-triisopropylsilanyloxy-benzyl)-16-isopropyl-4,9,11,13-tetramethyl-2,5,8-trioxo-1-oxa-4,7-diaza-cyclohexadec-14-yl ester 
• 333354-24-8 (2S,4S,6R,7S,9S)-9-[(R)-2-[(2-tert-Butoxycarbonylamino-acetyl)-methyl-amino]-3-(3-iodo-4-triisopropylsilanyloxy-phenyl)-propionyloxy]-7-(tert-butyl-dimethyl-silanyloxy)-2,4,6,10-tetramethyl-undecanoic acid tert-butyl ester 

Relevant academic research and scientific papers

Diverted total synthesis of the baulamycins and analogues reveals an alternate mechanism of action

The baulamycins were identified as in vitro siderophore biosynthesis inhibitors. Diverted total synthesis was used to construct the natural products and eight strategic analogues, three of which had improved inhibitory activity. Biological testing then revealed that membrane damage is the predominant mode of action in Staphylococcus aureus cells.

Catalytic, efficient, and syn-selective construction of deoxypolypropionates and other chiral compounds via Zr-catalyzed asymmetric carboalumination of allyl alcohol

An efficient, syn-selective, all catalytic asymmetric protocol for the synthesis of α,ω-diheterofunctional deoxypolypropionates via Zr-catalyzed asymmetric carboalumination (ZACA reaction) was developed. The success of the method critically hinges on the

Total synthesis of antitumor depsipeptide (-)-doliculide.

[reaction: see text] (-)-Doliculide, a potent antitumor agent, is synthesized stereoselectively in a convergent manner. The key strategy involves a stereoselective synthesis of the polyketide unit and synthesis of the D-tyrosine derivative, followed by as