55231-61-3

Upstream product

• 50-00-0 formaldehyd 
• 108-67-8 1,3,5-trimethyl-benzene 

Downstream Products

• 348596-90-7 1,3-bis(1-imidazol-1-ylmethyl)-2,4,6-trimethylbenzene 
• 250651-10-6 1,3-bis(azidomethyl)-2,4,6-trimethylbenzene 
• 70477-53-1 1,3,5-Trimethyl-2,4-bis-thiocyanatomethyl-benzene 
• 1497396-08-3 C₃₁H₃₈N₂O₂ 
• 1531633-03-0 1,3-bis(2-(2-hydroxyphenyl)benzimidazol-1-ylmethyl)-2,4,6-trimethylbenzene 

Relevant academic research and scientific papers

C3i-symmetric octanuclear cadmium cages: Double-anion-templated synthesis, formation mechanism, and properties

A series of C3i-symmetric bicapped trigonal antiprismatic Cd8 cages [2X@Cd8L6(H2O) 6]?n Y?solvents (X=Cl-, Y=NO3 -, n=2: MOCC-4; X=Br-, Y=NO

A mesitylene-bridged bis-benzimidazolyl ligand and six metal coordination compounds

The mesitylene-bridged bis-benzimidazolyl ligand 1,3-bis(benzimidazol-1′-yl-methyl)mesitylene (L) and six metal complexes, [Cu9L6(OH)7Cl8] (1), [Co2L4(NO3)(H2O)2

2,4-bis(bromomethyl)-1,3,5-trimethylbenzene with 2-mercaptopyridine based derivative: Synthesis, crystal structure, in vitro anticancer activity, DFT, Hirshfeld surface analysis, antioxidant, DNA binding and molecular docking studies

The compound 2,2′-[(2,4,6-trimethyl-1,3 phenylene)bis(methylenesulfanediyl)]dipyridine (M2MCP) was synthesised by the condensation of 2,4-bis(bromomethyl)-1,3,5-trimethylbenzene with 2-mercaptopyridine. The crystal structure of the title molecule is Tricl

Paraoxonase Mimic by a Nanoreactor Aggregate Containing Benzimidazolium Calix and l-Histidine: Demonstration of the Acetylcholine Esterase Activity

An anion-mediated preorganization approach was used to design and synthesize the benzimidazolium-based calix compound R1?2 ClO4?. X-ray crystallography analysis revealed that the hydrogen-bonding interactions between the benzimidazol

Mechanistic basis of the inhibition of slc11/nramp-mediated metal ion transport by bis-isothiourea substituted compounds

In humans, the divalent metal ion transporter-1 (DMT1) mediates the transport of ferrous iron across the apical membrane of enterocytes. Hence, its inhibition could be beneficial for the treatment of iron overload disorders. Here we characterize the interaction of aromatic bis-isothiourea-substituted compounds with human DMT1 and its prokaryotic homologue EcoDMT. Both transporters are inhibited by a common competitive mechanism with potencies in the low micromolar range. The crystal structure of EcoDMT in complex with a brominated derivative defines the binding of the inhibitor to an extracellular pocket of the transporter in direct contact with residues of the metal ion coordination site, thereby interfering with substrate loading and locking the transporter in its outward-facing state. Mutagenesis and structure-activity relationships further support the observed interaction mode and reveal species-dependent differences between pro-and eukaryotic transporters. Together, our data provide the first detailed mechanistic insight into the pharmacology of SLC11/NRAMP transporters.

Potent anti-proliferative activities of organochalcogenocyanates towards breast cancer

The pharmacological importance, particularly the anti-cancer and chemopreventive potentials, of organochalcogen compounds has attracted wide research attention recently. Herein we describe the synthesis of a series of organochalcogenocyanates that have one or more selenocyanate or thiocyanate units in a single molecule. The anti-proliferative activity of these organochalcogenocyanates in different breast cancer cells shows that selenocyanates exhibit much higher anti-proliferative activities than thiocyanates in general. Our study reveals that the activity of benzyl selenocyanate (1, BSC) could be significantly enhanced by 4-nitro substitution (12), which was more selective towards triple-negative breast cancer cells (MDA-MB-231) over other ER+ breast cancer cells (MCF-7 and T-47D). Furthermore, to the best of our knowledge, this is the first report on the synthesis of compounds having more than two selenocyanate units with promising anti-proliferative activities. Our studies further indicate that the apoptotic activities of selenocyanates are associated with modulation of cellular morphology and cell cycle arrest at S-phase. Selenocyanates also inhibited cellular migration and exhibited weak antioxidant activities. An effective binding interaction of compound 12 with serum albumin indicates its feasible transport in the bloodstream for its enhanced anti-cancer properties. Mechanistic studies by western blot analysis demonstrate that benzylic selenocyanates exhibit anti-proliferative activities by modulating key cellular proteins such as Survivin, Bcl-2 and COX-2; this was further supported by molecular docking studies. The results of this study would be helpful in designing suitable chemotherapeutic and chemopreventive drugs in the future.

tooth benzene and imidazole ligands double-based metal complex and its preparation and use

The invention discloses a metal complex based on bis-benzimidazole ligand and a preparation method and a purpose thereof. According to the invention, benzimidazole, paraformaldehyde, 1, 3, 5-trimethyl benzene or the like are used as raw materials for synt

Application of novel multi-cationic ionic liquids in microwave assisted 2-amino-4H-chromene synthesis

Novel multi-cationic ionic liquids containing a mesitylene backbone with acetate and methane sulphonate anions have been synthesized. These ionic liquids were used for the synthesis of 2-amino-4H-chromenes under microwave heating. The effects of nature and amount of ionic liquids on the yield and reaction time were thoroughly investigated. The ionic liquids showed a considerable level of reusability without a significant decrease in catalytic activity. We have successfully combined the advantages of microwave technology with ionic liquids to facilitate the rapid construction of chromene skeletons from readily obtainable and inexpensive materials via a multicomponent strategy.

Homogeneous and semi-heterogeneous magnetically retrievable bis-n-heterocyclic carbene rhodium(I) based catalysts for selective hydroaminomethylation reactions

The preparation of various bis-N-heterocyclic carbene (bis-NHC) complexes of rhodium and their application in the hydroaminomethylation of vinyl arenes was investigated. Various reaction parameters such as solvent, temperature, and pressure were tested, and the optimized protocol was applied to a wide variety of vinyl arenes and amines to afford the corresponding amines in good yields with high selectivity towards the branched product. The bis-NHC-based catalyst demonstrated superior reactivity and selectivity compared to catalysts containing bidentate phosphine or monodentate NHC ligands. A triethoxysilyl-functionalized bis-NHC ligand was immobilized on magnetic nanoparticles and then utilized to bind a rhodium catalyst. The resulting catalytic system was successfully employed in hydroaminomethylation reactions. The catalyst exhibited excellent reactivity, high selectivity, and was simply recovered from the reaction medium by applying an external magnetic field. Various bis-N-heterocyclic carbene (bis-NHC) ligands are prepared and complexed with rhodium(I). Some of these complexes show excellent reactivity and high selectivity in homogeneous hydroaminomethylation reactions. A bis-NHC ligand derivative is supported on magnetite nanoparticles and after complexation with RhI is was applied successfully in semi-heterogeneous hydroaminomethylations.

Nanomolar detection of AgI Ions in aqueous medium by using naphthalimide-based imine-linked fluorescent organic nanoparticles - Application in environmental samples

The synthesis of fluorescent organic nanoparticles (FONPs) with an imine-linked 1,8-naphthalimide-based dipodal chemosensor for AgI is described. The FONPs were prepared by using a re-precipitation method, and they were successfully applied for