552336-44-4Relevant academic research and scientific papers
The total synthesis of (-)-tetrahydrolipstatin
Bodkin, Jennifer A.,Humphries, Edward J.,McLeod, Malcolm D.
, p. 795 - 803 (2003)
Careful control during the bromolactonization of β,γ-unsaturated acid (4) was required to regioselectivity afford the trans-β-lactone (3) as the major diastereomer. Radical debromination of (3) followed by a three-step sequence of reactions afforded the lipase inhibitor (-)-tetrahydrolipstatin (1).
The total synthesis of (-)-tetrahydrolipstatin
Bodkin, Jennifer A.,Humphries, Edward J.,McLeod, Malcolm D.
, p. 2869 - 2872 (2007/10/03)
Careful control during the bromolactonisation of β,γ-unsaturated acid 3 was required to afford regioselectively the trans-β-lactone 4 as the major diastereomer. Radical debromination of 4 followed by a three-step sequence of reactions afforded the lipase inhibitor (-)-tetrahydrolipstatin.
