55239-76-4

Upstream product

• 75-44-5 phosgene 
• 932-32-1 N-methyl-2-chloroaniline 
• 32315-10-9 bis(trichloromethyl) carbonate 
• 95-51-2 o-chloroaniline 

Downstream Products

• 22782-20-3 C₂₄H₃₁ClN₄O₄S 
• 22782-21-4 C₂₁H₂₇ClN₄O₄S 
• 22782-19-0 4-{2-[3-(2-Chloro-phenyl)-3-methyl-ureido]-ethyl}-benzenesulfonamide 

Relevant academic research and scientific papers

Rhodium catalyzed regioselective arene homologation of aryl urea via double C–H bond activation and migratory insertion of alkyne

A convenient rhodium catalyzed oxidative arene homologation of aniline derivatives with symmetrical or unsymmetrical alkynes using Cu(OAc)2as oxidant is described. Urea group is shown to be effective as a directing group for initial ortho C–H activation. Two migratory insertion events of alkyne into Rh–C bond occur successively, both with complete regioselectivity. This method is particularly useful for synthesis of polyarenes with different substituents, which has not been reported with conventional protocol. A mechanism has been proposed to explain the observed data.