55241-49-1

Usage

Uses

Used in Pharmaceutical Industry:
1,3-DIMETHYL-2-OXO-2,3-DIHYDRO-1H-BENZIMIDAZOLE-5-CARBALDEHYDE is used as a reagent for the synthesis and study of in vitro p38 structure activity of benzimidazolone inhibitors. Its application in this field is due to its ability to interact with and modulate the activity of p38, a protein kinase involved in various cellular processes, including inflammation and immune responses. By studying the interactions between 1,3-DIMETHYL-2-OXO-2,3-DIHYDRO-1H-BENZIMIDAZOLE-5-CARBALDEHYDE and p38, researchers can gain insights into the development of new drugs targeting this protein for various therapeutic applications.

InChI:InChI=1/C10H10N2O2/c1-11-8-4-3-7(6-13)5-9(8)12(2)10(11)14/h3-6H,1-2H3

Upstream product

• 3097-21-0 1,3-dimethyl-1,3-dihydrobenzimidazol-2-one 
• 4885-02-3 Dichloromethyl methyl ether 
• 222424-21-7 methyl 1,3-dimethyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazole-5-carboxylate 
• 345657-96-7 5-(hydroxymethyl)-1,3-dimethylbenzimidazol-2-one 

Downstream Products

• 1428968-43-7 5-(2-(1H-indol-3-yl)-1-((3-methoxyphenyl)amino)-2-oxoethyl)-1,3-dimethyl-1H-benzo[d]imidazol-2(3H)-one 

Relevant academic research and scientific papers

Benzimidazolone p38 inhibitors

The synthesis and in vitro p38α activity of a novel series of benzimidazolone inhibitors is described. The p38α SAR is consistent with a mode of binding wherein the benzimidazolone carbonyl serves as the H-bond acceptor to Met109 of p38α in a manner analogous to the pyridine nitrogen of prototypical pyridylimidazole p38 inhibitors. Potent p38α activity comparable to that of several previously reported p38 inhibitors is observed for this novel chemotype.

C-formylation of some 2(3H)-benzazolones and 2H-1,4-benzoxazin-3(4H)-one

The C-formylation of 1,3-dimethyl-2(3H)-benzimidazolone and 4-methyl-2H-1,4-benzoxazin-3(4H)-one was performed using 1,1-dichloromethyl methyl ether at the Friedel-Crafts reaction conditions. The formylation of 3-methyl-2(3H)-benzoxa-and -thiazolone at the 6-position was carried out by modified Duffs method with hexamethylenetetramine in trifluoroacetic acid.