55251-17-7Relevant academic research and scientific papers
Convenient synthesis of N-alkoxymethylbarbituric acids and N-alkoxymethylhydantoins
Gal
, p. 1562 - 1564 (1979)
A simple one-step method for the N-alkoxymethylation of barbituric acids and hydantoins is presented. The compounds are N-methoxymethylated or N-ethoxymethylated using phosphorus pentoxide and dimethoxymethane or diethoxymethane, respectively, in a chlorinated solvent. 1-Methoxymethyl-3-ethyl-5-phenylhydantoin showed significant anticonvulsant activity in the subcutaneous pentylenetetrazol test, while 1,3-bis(methoxymethyl)-5-ethyl-5-(p-tolyl)barbituric acid was inactive.
