Journal of Pharmaceutical Sciences p. 1562 - 1564 (1979)
Update date:2022-08-02
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A simple one-step method for the N-alkoxymethylation of barbituric acids and hydantoins is presented. The compounds are N-methoxymethylated or N-ethoxymethylated using phosphorus pentoxide and dimethoxymethane or diethoxymethane, respectively, in a chlorinated solvent. 1-Methoxymethyl-3-ethyl-5-phenylhydantoin showed significant anticonvulsant activity in the subcutaneous pentylenetetrazol test, while 1,3-bis(methoxymethyl)-5-ethyl-5-(p-tolyl)barbituric acid was inactive.
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Doi:10.1021/ol9904085
(2000)Doi:10.1007/BF00900782
(1953)Doi:10.1016/S0022-328X(98)01001-8
(1999)Doi:10.1021/ja01326a073
(1934)Doi:10.1021/acs.joc.9b01548
(2019)Doi:10.1016/S0040-4020(01)88389-7
(1990)
