Journal of Pharmaceutical Sciences p. 1562 - 1564 (1979)
Update date:2022-08-02
Topics:
Gal
A simple one-step method for the N-alkoxymethylation of barbituric acids and hydantoins is presented. The compounds are N-methoxymethylated or N-ethoxymethylated using phosphorus pentoxide and dimethoxymethane or diethoxymethane, respectively, in a chlorinated solvent. 1-Methoxymethyl-3-ethyl-5-phenylhydantoin showed significant anticonvulsant activity in the subcutaneous pentylenetetrazol test, while 1,3-bis(methoxymethyl)-5-ethyl-5-(p-tolyl)barbituric acid was inactive.
View MoreZouping Fuhai Technology Development Co., Ltd.
Contact:+0532-86934525 18660293207
Address:jiuhu town industrial park Zouping County,bingzhou Provincejiuhu town industrial park
Contact:732.938.2777
Address:5012 Industrial Road Farmingdale, NJ 07727
Contact:+86 512 6287 2180
Address:398 Ruoshui Road, Suzhou Industrial Park, Suzhou, Jiangsu, P. R. China
JiangXi Hong Run Chemical Co., Ltd
Contact:+86-0791-88521351
Address:XingHuo industrial zone in YongXiu county
Liaoyang Xinyou Chemical Products Co.,Ltd.
Contact:+86-419-5165433 13604191870
Address:Huishang Road6-1, Hongwei District, Liaoyang, Liaoning, China
Doi:10.1021/ol9904085
(2000)Doi:10.1007/BF00900782
(1953)Doi:10.1016/S0022-328X(98)01001-8
(1999)Doi:10.1021/ja01326a073
(1934)Doi:10.1021/acs.joc.9b01548
(2019)Doi:10.1016/S0040-4020(01)88389-7
(1990)
