55255-53-3Relevant articles and documents
Copper-catalyzed direct transformation of secondary allylic and benzylic alcohols into azides and amides: An efficient utility of azide as a nitrogen source
Rokade, Balaji V.,Gadde, Karthik,Prabhu, Kandikere Ramaiah
, p. 2706 - 2717 (2015/04/27)
A mild and convenient method for the synthesis of amides has been explored by using secondary alcohols, Cu(ClO4)2·6H2O as a catalyst, and trimethylsilyl azide (TMSN3) as a nitrogen source in the presence of 2,3-dichloro-5,6-dicyano-p-benzoquinone (DDQ) at ambient temperature. This method has been successfully adapted to the preparation of azides directly from their corresponding alcohols and offers excellent chemoselectivity in the formation of ω-halo azides and the azidation of allylic alcohols in the presence of a benzyl alcohol moiety. In addition, this strategy provides an opportunity to synthesize azides that can serve as precursors to β-amino acids. A mild and convenient method for the synthesis of amides has been explored by using secondary alcohols, Cu(ClO4)2·6H2O as a catalyst, and trimethylsilyl azide (TMSN3) as a nitrogen source in the presence of 2,3-dichloro-5,6-dicyano-p-benzoquinone (DDQ) at ambient temperature. This method has also been adapted to the preparation of azides directly from their corresponding alcohols.
The triflic acid-mediated cyclization reactions of N-cinnamoyl-1- naphthylamines
King, Frank D.,Aliev, Abil E.,Caddick, Stephen,Tocher, Derek A.
, p. 10938 - 10946 (2013/11/19)
N-Cinnamoyl-1-naphthylamines undergo a cyclization reaction with triflic acid to form 4-phenyl-3,4-dihydro-1H-naphth[1,8-bc]azepin-2-ones and 4-phenyl-3,4-dihydro-1H-benzo[h]quinolin-2-ones. However, the N-benzyl analogues also undergo a unique cascade re
Anti-inflammatory activity of some novel α-amino naphthalene derivatives
Sharma, Shalabh,Srivastava, Virendra Kishore,Kumar, Ashok
, p. 44 - 52 (2007/10/03)
α-Acetylamino naphthalene (1) was reacted with different aromatic aldehydes and with primary or secondary amines to give α-aminonaphthylsubstitutedaryl chalkones (2-5) and α-(substituted aminoethyl)-amidonaphthalenes (14-25), respectively. These substituted chalkones were treated with hydrazinehydrate and hydroxylamine hydrochloride to give 1-acetyl-5-substitutedaryl-3-(α-aminonaphthyl)-2-pyrazolines (6-9)0000000000000000000000000000000 and α-(2-substitutedaryl-isoxazolin-4-yl)-aminonaphthalenes (10-13), respectively. Their chemical structures were confirmed by IR and 1H-NMR spectral data and elemental analysis. Studies of the anti-inflammatory and ulcerogenic activities and acute toxicity of these newly synthesized compounds were performed in vivo and compared with the standard drug, phenylbutazone (CAS 50-33-9). Some of these compounds showed potent anti-inflammatory activity and less ulcerogenic effects than phenylbutazone.
Palladium(II)-catalyzed regioselective carbonylative coupling of aniline derivatives with terminal aryl acetylenes to give acrylamides under syngas conditions
El Ali,El-Ghanam,Fettouhi,Tijani
, p. 5761 - 5764 (2007/10/03)
The carbonylative coupling of aniline derivatives (1a-h) with terminal aryl acetylenes (2a, b) catalyzed by Pd(OAc)2 and 1,4- bis(diphenylphosphino)butane (dppb) under syngas conditions affords acrylamide derivatives 3 or 3' in excellent yields
Photocyclization of Enamides. Part 20. Photocyclization of N-Naphthylacrylamides and Synthesis of the Basic Indoloquinoline Nucleus of Ergot Alkaloids
Ninomiya, Ichiya,Hashimoto, Chiyomi,Kiguchi, Toshiko,Naito, Takeaki
, p. 2967 - 2972 (2007/10/02)
Photocyclization of some N-naphthylacrylamides (1)-(6) provided a general synthetic route to benzo- and benzo-quinolines (7)-(12) and two compounds containing the basic indoloquinoline nucleus of ergot alkaloids, (17), and (21), were readily
