55280-98-3Relevant academic research and scientific papers
Beta adrenergic blocking activity of benzo bicyclic derivatives: a search for cardiac selectivity
Vecchietti,Lauria,Tommasini,Bergamaschi
, p. 501 - 507 (2007/10/06)
A series of 3 amino 2 hydroxypropoxy derivatives of 1,2,3,4 tetrahydro 1,4 methanonaphthalene and 1,2,3,4 tetrahydro 1,4 ethanonaphthalene was synthesized. Structural requirements for blockade of beta adrenoceptors in heart and lung and local anesthetic and quinidine like activities were investigated. Several compounds showed a considerable selective activity on cardiac (β1) adrenoceptors, and low unspecific membrane effect and were selected for further studies.
