552885-90-2Relevant academic research and scientific papers
Synthesis of diphenylmethyl analogues and their affinity for the melanocortin-4 receptor and the serotonin transporter
Nozawa, Dai,Okubo, Taketoshi,Ishii, Takaaki,Chaki, Shigeyuki,Okuyama, Shigeru,Nakazato, Atsuro
, p. 1044 - 1050 (2007)
While examining antagonists of the melanocortin-4 receptor (MC4 receptor), we found that compound 12b, containing a diphenylmethyl moiety, had a relatively high affinity for the MC4 receptor. When diphenylmethyl analogues were further examined, compounds
PIPERAZINE DERIVATIVE
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Page 29, (2010/02/08)
A piperazine derivative represented by the formula (1): ???wherein n is an integer of 1 to 8; R1 represents hydrogen or C1-10 alkyl; A represents CH or nitrogen; Ar1 represents phenyl or substituted phenyl; and Y represents a group represented by the formula Y1-Y2-Ar2 or Y3-Y4(Ar5)-Ar6 or a pharmaceutically acceptable salt of the derivative. The novel piperazine derivative has MC4 receptor antagonistic activity.
