55293-96-4Relevant articles and documents
Synthesis of filibuvir. Part III. Development of a process for the reductive coupling of an aldehyde and a β-keto-lactone
Ide, Nathan D.,Ragan, John. A.,Bellavance, Gabriel,Brenek, Steve J.,Cordi, Eric M.,Jensen, Grace O.,Jones, Kris N.,France, Danny La,Leeman, Kyle R.,Letendre, Leo J.,Place, David,Stanchina, Corey L.,Sluggett, Gregory W.,Strohmeyer, Holly,Blunt, Jon,Meldrum, Kevin,Taylor, Stuart,Byrne, Ciaran,Lynch, Denis,Mullane, Sandra,O'Sullivan, Maria M.,Whelan, Marcella
, p. 45 - 56 (2014/05/20)
Development of a reductive coupling of a β-keto-lactone and an aldehyde is described, in which the Hantzsch ester serves as an inexpensive and convenient reducing agent. Structural features in the β-keto-lactone rendered standard reductive coupling conditions ineffective, requiring development of a specific addition and temperature protocol. Identification of one of the reactants as Ames positive required a single-digit parts per million control strategy for this impurity in the final active pharmaceutical ingredient (API).
METHODS FOR THE PREPARATION OF HCV POLYMERASE INHIBITORS
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Page/Page column 55-56, (2008/06/13)
The present invention relates to methods and compounds useful in the preparation of compounds of the formula (I).
INHIBITORS OF HEPATITIS C VIRUS RNA-DEPENDENT RNA POLYMERASE, AND COMPOSITIONS AND TREATMENTS USING THE SAME
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Page/Page column 104, (2008/06/13)
The present invention provides compounds of formula (4), and their pharmaceutically acceptable salts and solvates, which are useful as inhibitors of the Hepatitis C virus (HCV) polymerase enzyme and are also useful for the treatment of HCV infections in HCV-infected mammals. The present invention also provides pharmaceutical compositions comprising compounds of formula (4), their pharmaceutically acceptable salts and solvates. Furthermore, the present invention provides intermediate compounds and methods useful in the preparation of compounds of formula (4).