55304-83-1 Usage
Uses
Used in Pharmaceutical Industry:
2,6-Dibromopyridine-3-carboxaldehyde serves as a key building block in the synthesis of various pharmaceuticals. Its unique structure and reactivity make it a valuable intermediate for the development of new drugs, particularly those targeting specific biological pathways or receptors.
Used in Agrochemical Industry:
In the agrochemical sector, 2,6-Dibromopyridine-3-carboxaldehyde is utilized in the production of pesticides and other crop protection agents. Its chemical properties allow for the creation of compounds that can effectively control pests and diseases in agriculture, contributing to increased crop yields and food security.
Used in Dye Manufacturing:
2,6-Dibromopyridine-3-carboxaldehyde is employed in the manufacturing of dyes due to its ability to form colored compounds. These dyes find applications in various industries, including textiles, plastics, and printing inks, where colorfast and vibrant dyes are required.
Used in Materials Science:
In the field of materials science, 2,6-Dibromopyridine-3-carboxaldehyde is used to develop new materials with specific properties. Its reactivity and structural features enable the creation of materials with tailored characteristics, such as improved conductivity, stability, or specific interactions with other molecules.
Safety Considerations:
Given its high reactivity, 2,6-Dibromopyridine-3-carboxaldehyde should be handled with care in a controlled laboratory environment. Proper safety measures, including the use of personal protective equipment and adherence to established laboratory protocols, are essential to minimize risks associated with its use.
Check Digit Verification of cas no
The CAS Registry Mumber 55304-83-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,5,3,0 and 4 respectively; the second part has 2 digits, 8 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 55304-83:
(7*5)+(6*5)+(5*3)+(4*0)+(3*4)+(2*8)+(1*3)=111
111 % 10 = 1
So 55304-83-1 is a valid CAS Registry Number.
InChI:InChI=1/C6H3Br2NO/c7-5-2-1-4(3-10)6(8)9-5/h1-3H
55304-83-1Relevant articles and documents
Synthesis of a muscarinic receptor antagonist via a diastereoselective Michael reaction, selective deoxyfluorination and aromatic metal-halogen exchange reaction
Mase,Houpis,Akao,Dorziotis,Emerson,Hoang,Iida,Itoh,Kamei,Kato,Kato,Kawasaki,Lang,Lee,Lynch,Maligres,Molina,Nemoto,Okada,Reamer,Song,Tschaen,Wada,Zewge,Volante,Reider,Tomimoto
, p. 6775 - 6786 (2007/10/03)
An efficient synthesis of a structurally unique, novel M3 antagonist 1 is described. Compound 1 is conveniently disconnected retrosynthetically at the amide bond to reveal the acid portion 2 and the amine fragment 3. The synthesis of key intermediate 2 is highlighted by a ZnCl2-MAEP complex 19 catalyzed diastereoselective Michael reaction of dioxolane 7 with 2-cyclopenten-1-one (5) to establish the contiguous quaternary-tertiary chiral centers and a subsequent geminal difluorination of ketone 17 using Deoxofluor in the presence of catalytic BF3·OEt2. The synthesis of the amine moiety 3 is highlighted by the discovery of a novel n-Bu3MgLi magnesium-halogen exchange reaction for selective functionalization of 2,6-dibromopyridine. This new and practical metalation protocol obviated cryogenic conditions and upon quenching with DMF gave 6-bromo-2-formylpyridine (26) in excellent yield. Further transformations afforded the amine fragment 3 via reductive amination with 35, Pd-catalyzed aromatic amination, and deprotection. Finally, the highly convergent synthesis of 1 was accomplished by coupling of the two fragments. This synthesis has been used to prepare multi-kilogram quantities of the bulk drug.
