55307-50-1Relevant academic research and scientific papers
Iodine-Promoted Multicomponent Synthesis of 2,4-Diamino-1,3,5-triazines
Zhao, Peng,Zhou, You,Yu, Xiao-Xiao,Huang, Chun,Wu, Yan-Dong,Yin, Guodong,Wu, An-Xin
, p. 8528 - 8532 (2020)
A novel and efficient multicomponent cyclization of methyl ketones, cyanamides, and arylamines for the synthesizing 2,4-diamino-1,3,5-triazines via consecutive formation of four C-N bonds is reported. This multicomponent reaction is characterized by the employment of two molecules of cyanamide for double C(sp3)-H amination of methyl ketones, avoiding complicated prepreparation of substrates and expanding the substrate scope. Furthermore, this multicomponent cyclization strategy provides a new approach for generating diverse 2,4-diamino-1,3,5-triazines with a broad substrate scope under mild conditions.
