55330-52-4Relevant academic research and scientific papers
2, 6 BISHETEROARYL-4-AMINOPYRIMIDINES AS ADENOSINE RECEPTOR ANTAGONISTS
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Page/Page column 87, (2010/02/12)
4-Aminopyrimidine derivatives of formula (I) FORMULA heteroaryl groups, including pharmaceutically acceptable salts thereof, wherein R1 and R2 are adenosine A2A receptor antagonists useful in the treatment of movement disorders such as Parkinson's disease.
A new expedient route to 2,6-diaryl-3-cyano-4- (trifluoromethyl)pyridines
Yamaguchi,Katsuyama,Funabiki,Matsui,Shibata
, p. 805 - 810 (2007/10/03)
1-Aryl-4,4,4-trifluoro-1,3-butanediones 1 react with β-amino-β- arylacrylonitrile 2, readily available from acetonitrile with aryl nitriles in the presence of potassium t-butoxide, to afford the corresponding 2,6- diaryl-3-cyano-4-(trifluoromethyl)pyridin
CYCLOCONDENSATION OF α-OXOKETENE DITHIOACETALS WITH β-LITHIOAMINO-β-SUBSTITUTED ACRYLONITRILES: SYNTHESIS OF 2,6-SUBSTITUTED AND 5,6-ANNELATED 3-CYANO-4-(METHYLTHIO)PYRIDINES
Gupta, Arun K.,Ila, Hiriyakkanavar,Junjappa, Hiriyakkanavar
, p. 3703 - 3714 (2007/10/02)
The lithiated β-amino-β-substituted acrylonitriles 4a-d generated in situ by reaction of lithioacetonitrile with either acetonitrile or substituted nitriles undergo cyclocondensation with α-oxoketenedithioacetate through 1,4-addition to afford 2,6-substit
β Aminocinnamonitriles as potential antiinflammatory agents
Lang Jr.,Cohen
, p. 441 - 443 (2007/10/08)
A number of β aminocinnamonitriles have been prepared by the reaction of salts of acetonitrile and proprionitrile with benzonitrile. These materials were evaluated in the carrageenan antiinflammatory screen in Royal Hart, Wistar strain rats. Despite food weight gains with the parent molecule, β aminocinnamonitrile, only marginal activity was found in related compounds and some possible 'metabolites'.
