55338-97-1

Upstream product

• 403-42-9 1-(4-fluorophenyl)ethanone 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 925005-35-2 5-(4-fluorophenyl)-3-aminoisoxazole 
• 205984-77-6 3-chloro-3-(4-fluorophenyl)acrylonitrile 
• 575433-43-1 3-(4-fluorophenyl)-2-propynenitrile 
• 126417-77-4 (Z)-3-chloro-3-(4-fluorophenyl)-2-propenenitrile 
• 1334951-27-7 1-(2-fluorophenyl)-3-(4-fluorophenyl)-1H-pyrazole 
• 1326780-62-4 2-(4-chlorophenyl)-3-(4-fluorophenyl)isoxazol-5(2H)-one 
• 1227403-42-0 (2E,4Z)-5-chloro-5-(4-fluorophenyl)-1-(2-hydroxy-4,6-dimethoxyphenyl)penta-2,4-dien-1-one 
• 1224257-81-1 5-chloro-5-(4-fluorophenyl)-1-(4-methoxyphenyl)penta-2,4-dien-1-one 
• 1224257-75-3 5-chloro-1-(2,4-dimethoxyphenyl)-5-(4-fluorophenyl)penta-2,4-dien-1-one 
• 55338-81-3 [(Z)-3-Chloro-3-(4-fluoro-phenyl)-1-hydroxy-allyl]-phosphonic acid diethyl ester 

Relevant academic research and scientific papers

Novel benzenesulfonamide-bearing pyrazoles and 1,2,4-thiadiazoles as selective carbonic anhydrase inhibitors

Two series comprising 20 novel benzenesulfonamides bearing thioureido-linked pyrazole 8 and amino-1,2,4-thiadiazole 10 were synthesized and assayed as human carbonic anhydrase (hCA) inhibitors against isoforms I and II as well as the tumor-associated isof

A general and efficient approach to 2H-indazoles and 1H-pyrazoles through copper-catalyzed intramolecular N-N bond formation under mild conditions

A new efficient copper-catalyzed intramolecular amination reaction has been developed to readily synthesise a wide variety of multi-substituted 2H-indazole and 1H-pyrazole derivatives from easily accessible starting materials under mild conditions. A highly selective ligand for estrogen receptor β was prepared in three steps by employing this method. The Royal Society of Chemistry 2011.

Synthesis and biological screening of a combinatorial library of β-chlorovinyl chalcones as anticancer, anti-inflammatory and antimicrobial agents

A combinatorial library of β-chlorovinyl chalcones (4) were synthesized by Claisen-Schmidt condensation reaction. Catalytic reaction of substituted 3-chloro-3-phenyl-propenal (2) and 1-(2,4-dimethoxy-phenyl)-ethanone or 1-(4-methoxy-phenyl)-ethanone (3) i

Synthesis and biological evaluation of β-chloro vinyl chalcones as inhibitors of TNF-α and IL-6 with antimicrobial activity

A series of β-chloro vinyl chalcones have been synthesized by Claisen-Schmidt condensation. β-chloro vinyl aldehyde has been synthesized by the Vilsmayer-Hack formylation reaction. The structures of the newly synthesized compounds were confirmed by 1H NMR, IR and Mass spectral analysis. All the compounds were evaluated for their anti-inflammatory activity (against TNF-α and IL-6) and antimicrobial (antibacterial and antifungal) activity. Compounds 5a, 5d, 5e, 5g and 5i exhibited promising activity against IL-6 with 58-83% inhibition at 10 μM concentration. None of the compound was found to be cytotoxic in CCK-8 cells at 10 μM concentration. Whereas compounds 5b, 5d, 5e and 5i showed very good antibacterial activity and compounds 5a, 5b, 5e and 5i showed good antifungal activity.

SYNTHESIS OF NEW 2,5-DIARYL SELENOPHENES

A synthesis of 2,5-parasubstituted diaryl selenophenes is described. β-Aryl-β-chloro acroleins, easily prepared from substituted acetophenones and Vilsmaier-Haack reagent, are condensed with appropriate benzylbromide derivatives to give the title compound