55343-28-7

Basic information

• Product Name: 9-(2-Hydroxyethyl)-N⁶-benzoyladenine
• Synonyms: 9-(2-Hydroxyethyl)-N⁶-benzoyladenine
• CAS NO: 55343-28-7
• Molecular Weight: 283.29
• Mol File: 55343-28-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 9-(2-Hydroxyethyl)-N⁶-benzoyladenine(CAS DataBase Reference)
• NIST Chemistry Reference: 9-(2-Hydroxyethyl)-N⁶-benzoyladenine(55343-28-7)
• EPA Substance Registry System: 9-(2-Hydroxyethyl)-N⁶-benzoyladenine(55343-28-7)

Safety Data

• Hazardous Substances Data: 55343-28-7(Hazardous Substances Data)

Upstream product

• 98-88-4 benzoyl chloride 
• 707-99-3 9-(2-hydroxyethyl)adenine 

Downstream Products

• 135711-65-8 3'-Deoxy-5'-O-(monomethoxytrityl)-N⁶-<2-(4-nitrophenyl)ethoxycarbonyl>adenylyl-(2'-(O^P-<2-(4-nitrophenyl)ethyl>)->5')-3'-deoxy-N⁶-<2-(4-nitrophenyl)ethoxycarbonyl>adenylyl-(2'-(O^P-<2-nitrophenyl)ethyl)->2')-N⁶-benzoyl-9-(2'-hydroxyethyl)..... 
• 106941-25-7 Adefovir 
• 123156-01-4 9-(2-diethoxyphosphonylethyl)-N⁶-benzoyladenine 

Relevant articles and documents

Intramolecular cyclization of some acyclic nucleoside analogs

Reaction of stereoisomeric 8-bromo-9-(2,3-O-isopropylidene-2,3,4-trihydroxybutyl)adenines (8) with concentrated aqueous ammonia, sodium hydride, potassium tert-butoxide, or 1,8-diazabicyclo-[5,4,0]undec-7-ene afforded 4′-O,8-anhydro-9-(2,3-O-isopropyliden

SYNTHESIS OF 9-(2-PHOSPHONYLMETHOXYETHYL)ADENINE AND RELATED COMPOUNDS

Diethyl 2-hydroxyethoxymethanephosphonate (VIII) was converted into diethyl 2-halogenoethoxymethanephosphonates IXa and IXb by reaction with triphenylphosphine and tetrachloromethane or tetrabromomethane; analogous reaction of VIII with p-toluenesulfonyl chloride afforded diethyl 2-(p-toluenesulfonyloxy)ethoxymethanephosphonate (IXc).Reaction of sodium salt of adenine with compounds IX led to 9-(2-diethoxyphosphonylmethoxyethyl)adenine (X).Compound X was converted into 9-(2-phosphonylmethoxyethyl)adenine (II) by treatment with bromotrimethylsilane whereas alkaline hydrolysis of X gave ethyl ester Vb.Reaction of 9-(2-hydroxyethyl)adenine (IIIa) or its N6-benzoyl derivative IIIb with dimethyl p-toluenesulfonyloxymethanephosphonate (IV) in the presence of sodium hydride, followed by alkaline hydrolysis yielded methyl ester Va.Morpholide XI reacted with an inorganic phosphate and diphosphate to give 9-(2-phosphorylphosphonylmethoxyethyl)adenine (XII) and 2-(diphosphorylphosphonylmethoxyethyl)adenine (XIII), respectively.