40546-94-9

Basic information

• Product Name: 6-Methyl-4-phenylchroman-2-one
• Synonyms: forTolterodine-L-tartrate;6-METHYL-4-PHENYL-3,4-DIHYDRO-2H-1-BENZOPYRAN-2-ONE;6-METHYL-4-PHENYL-CHROMAN-ONE;6-METHYL-4-PHENYL-3,4-DIHYDRO-2H-1-BENZOPYRAN;6-Methyl-4-phenyl-2-chromanone;Dihydro methyl phenyl benzopyran one;rac-6-Methyl-4-phenylchroMan-2-one;2H-1-Benzopyran-2-one, 3,4-dihydro-6-Methyl-4-phenyl-
• CAS NO: 40546-94-9
• Molecular Formula: C₁₆H₁₄O₂
• Molecular Weight: 238.28
• Product Categories: Medicine intermediate;API intermediates;TOLTERODINE TARTRATE;(intermeidate of tolterodine);(intermediate of tolterodine tartrate);Benzenes;Aromatics;Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 40546-94-9.mol
• Article Data: 27

Chemical Properties

• Melting Point: 68-70°C
• Boiling Point: 230°C/16mmHg(lit.)
• Flash Point: 146.3 °C
• Appearance: /
• Density: 1.166 g/cm³
• Vapor Pressure: 4.2E-05mmHg at 25°C
• Refractive Index: 1.595
• Storage Temp.: Refrigerator
• Solubility: DMSO (Slightly), Methanol (Slightly)
• CAS DataBase Reference: 6-Methyl-4-phenylchroman-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Methyl-4-phenylchroman-2-one(40546-94-9)
• EPA Substance Registry System: 6-Methyl-4-phenylchroman-2-one(40546-94-9)

Safety Data

• Hazardous Substances Data: 40546-94-9(Hazardous Substances Data)

Usage

Chemical Properties

White Solid

InChI:InChI=1/C16H14O2/c1-11-7-8-15-14(9-11)13(10-16(17)18-15)12-5-3-2-4-6-12/h2-9,13H,10H2,1H3

Upstream product

• 106-44-5 p-cresol 
• 140-10-3 (E)-3-phenylacrylic acid 
• 99429-99-9 4-methylphenyl cinnamate 
• 16299-22-2 6-methyl-4-phenylchromen-2-one 
• 621-82-9 Cinnamic acid 
• 103-26-4 Methyl cinnamate 
• 99429-99-9 4-methylphenyl (2E)-3-phenylprop-2-enoate 
• 92-48-8 6-methylcoumarin 
• 98-80-6 phenylboronic acid 
• 345948-96-1 6-methyl-2-oxo-2H-chromen-4-yl 4-methylbenzenesulfonate 
• 613-84-3 2-hydroxy-5-methylbenzaldehyde 
• 55359-68-7 2-(methoxymethoxy)-5-methylbenzaldehyde 
• 103-36-6 ethyl 3-phenyl-2-propenoate 
• 102-92-1 cinnamoyl chloride 

Downstream Products

• 851789-43-0 3-phenyl-3-(2'-hydroxy-5'-methyl)phenylpropanol-1 
• 124937-51-5 (R)-(+)-tolterodine 
• 209747-04-6 2-hydroxy-6-methyl-4-phenyldihydrobenzopyran 
• 1043911-42-7 N,N-diisopropyl-3-(2-hydroxy-5-methylphenyl)-3-phenyl-propylamine L-tartrate 
• 124936-74-9 N,N-diiso-propyl-3-(2-hydroxy-5-methylphenyl)-3-phenylpropanamine 
• 16299-22-2 6-methyl-4-phenylchromen-2-one 
• 109089-77-2 3-(2-methoxy-5-methyl-phenyl)-3-phenyl-propionic acid 
• 837376-36-0 3-(2-hydroxy-5-methylphenyl)-N,N-diisopropyl-3-phenylpropan-1-aminium bromide 
• 156755-37-2 {4-(benzyloxy)-3-[(1R)-3-(dipropan-2-ylamino)-1-phenylpropyl]phenyl}methanol 
• 848768-06-9 (R)-3-[2-(benzyloxy)-5-methylphenyl]-N,N-diisopropyl-3-phenylpropan-1-amine 
• 124937-52-6 tolterodine tartrate 

Relevant articles and documents

Synthesis and Antioxidant Properties of New Substituted 8-Methyl-6-phenyl-5,6-dihydro-4H-1,3,2-benzodioxaphosphocine-2-oxide Derivatives

A new route for the synthesis of substituted 8-methyl-6-phenyl-5,6-dihydro-4H-1,3,2-benzodioxaphosphocine-2-oxide derivatives has been developed by using cinnamic acid and p-cresol via condensation, reduction, and followed by phosphorylation steps. The ti

Palladium Catalyzed Enantioselective Hayashi-Miyaura Reaction for Pharmaceutically Important 4-Aryl-3,4-dihydrocoumarins

The first palladium-catalyzed asymmetric addition of arylboronic acids to coumarins was successfully established, providing a straightforward asymmetric approach to achieving pharmaceutically important 4-aryl-3,4-dihydrocoumarins. This methodology features easily accessible and bench-stable ligands, a wide substrate scope, mild conditions, and accommodation of electron-withdrawing arylboronic acids.

Metal-free annulative hydrosulfonation of propiolate esters: synthesis of 4-sulfonates of coumarins and butenolides

An efficient metal-free and cost-effective method for the synthesis of coumarin and butenolide 4-sulfonates (46 examples) has been developed. The reaction involves addition of sulfonic acids to ethyl propiolates followed by lactonization, resulting in direct formation of coumarin and butenolide 4-sulfonates. This methodology has been elaborated to Sonogashira and Suzuki coupling including the synthesis of rac-tolterodine.