553616-04-9

Basic information

• Product Name: N-(4-chlorobenzenesulfonyl)-N-(2-fluorobenzyl)-D-leucinamide
• Synonyms: N-(4-chlorobenzenesulfonyl)-N-(2-fluorobenzyl)-D-leucinamide
• CAS NO: 553616-04-9
• Molecular Weight: 412.913
• Mol File: 553616-04-9.mol

Chemical Properties

• CAS DataBase Reference: N-(4-chlorobenzenesulfonyl)-N-(2-fluorobenzyl)-D-leucinamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-chlorobenzenesulfonyl)-N-(2-fluorobenzyl)-D-leucinamide(553616-04-9)
• EPA Substance Registry System: N-(4-chlorobenzenesulfonyl)-N-(2-fluorobenzyl)-D-leucinamide(553616-04-9)

Safety Data

• Hazardous Substances Data: 553616-04-9(Hazardous Substances Data)

Upstream product

• 446-48-0 o-fluorobenzyl bromide 
• 553619-61-7 (R)-2-(4-chlorobenzensulfonylamino)-4-methylpentanoic acid amide 
• 80970-09-8 (R)-2-amino-4-methylpentanamide hydrochloride 
• 98-60-2 4-chlorobenzenesulfonyl chloride 

Relevant articles and documents

Discovery of small molecular (d)-leucinamides as potent, Notch-sparing γ-secretase modulators

Structural optimization of the prior lead 3 led to the small molecular (d)-leucinamides with potent modulating activity and Notch-sparing selectivity on the proteolytic processing of amyloid-β precursor proteins. The N-(R)-epoxypropyl analog 10c exhibited