553638-66-7 Usage
Uses
Used in Pharmaceutical Synthesis:
(S)-2-[Bis(3,5-dimethylphenyl)methyl]pyrrolidine is used as a key intermediate in the synthesis of various pharmaceuticals, contributing to the development of new drugs with improved efficacy and selectivity.
Used in Agrochemical Development:
In the agrochemical industry, (S)-2-[Bis(3,5-dimethylphenyl)methyl]pyrrolidine is utilized as a building block for the creation of novel agrochemicals, potentially enhancing crop protection and yield.
Used in Materials Science:
(S)-2-[Bis(3,5-dimethylphenyl)methyl]pyrrolidine serves as a component in the development of new materials, leveraging its unique structural properties to improve material performance.
Used as a Chiral Ligand in Asymmetric Catalysis:
(S)-2-[Bis(3,5-dimethylphenyl)methyl]pyrrolidine is employed as a chiral ligand in asymmetric catalysis, where its stereochemistry plays a crucial role in influencing the outcome of chemical reactions, enabling the production of enantiomerically pure compounds.
Check Digit Verification of cas no
The CAS Registry Mumber 553638-66-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 5,5,3,6,3 and 8 respectively; the second part has 2 digits, 6 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 553638-66:
(8*5)+(7*5)+(6*3)+(5*6)+(4*3)+(3*8)+(2*6)+(1*6)=177
177 % 10 = 7
So 553638-66-7 is a valid CAS Registry Number.
InChI:InChI=1/C21H27N/c1-14-8-15(2)11-18(10-14)21(20-6-5-7-22-20)19-12-16(3)9-17(4)13-19/h8-13,20-22H,5-7H2,1-4H3/t20-/m0/s1
553638-66-7Relevant academic research and scientific papers
Enantioselective Silver and Amine Co-catalyzed Desymmetrizing Cycloisomerization of Alkyne-Linked Cyclohexanones
Manzano, Rubén,Datta, Swarup,Paton, Robert S.,Dixon, Darren J.
supporting information, p. 5834 - 5838 (2017/05/12)
A silver(I) and amine co-catalyzed desymmetrization of 4-propargylamino cyclohexanones for the direct enantioselective synthesis of 2-azabicyclo[3.3.1]nonanes is described. Exploiting reactivity arising from dual activation of the pendant terminal alkyne by silver(I) and the ketone moiety through transient enamine formation, this synthetically relevant transformation is easy to perform, efficient and broad in scope. High enantioselectivity (up to 96 % ee) was achieved by exploiting a significant matching effect between the chirality of a cinchona alkaloid-derived aminophosphine ligand for the silver(I) salt and the 2-bis(aryl)methylpyrrolidine catalyst which was rationalized by DFT calculations. This allowed for the preparation of both enantiomers of the bicyclic product with near-identical stereocontrol.
