55367-28-7

Basic information

• Product Name: 5-(furan-2-yl)-3-phenyl-4,5-dihydroisoxazole
• Synonyms: 5-(furan-2-yl)-3-phenyl-4,5-dihydroisoxazole
• CAS NO: 55367-28-7
• Molecular Weight: 213.236
• Mol File: 55367-28-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 5-(furan-2-yl)-3-phenyl-4,5-dihydroisoxazole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(furan-2-yl)-3-phenyl-4,5-dihydroisoxazole(55367-28-7)
• EPA Substance Registry System: 5-(furan-2-yl)-3-phenyl-4,5-dihydroisoxazole(55367-28-7)

Safety Data

• Hazardous Substances Data: 55367-28-7(Hazardous Substances Data)

Upstream product

• 98-01-1 furfural 
• 156605-56-0 1-phenylethan-1-one O-pivaloyl oxime 
• 55367-26-5 3,3'-di-furan-2-yl-1,1'-diphenyl-3,3'-hydroxyazanediyl-bis-propan-1-one 
• 1487-18-9 (furan-2-yl)ethylene 
• 873-67-6 benzonitrile oxide 
• 717-21-5 3-(furan-1-yl)-1-phenyl-prop-2-en-1-one 
• 39511-12-1 (E)-3-(furan-2-yl)-1-phenyl-2-propen-1-one 

Downstream Products

• 2976-10-5 5-(5-bromo-furan-2-yl)-3-phenyl-isoxazole 
• 14442-12-7 3-phenylisoxazole-5-carboxylic acid 
• 4872-58-6 3-phenyl-4,5-dihydroisoxazole-5-carboxylic acid 
• 2976-13-8 5-(2′-furyl)-3-phenylisoxazole 
• 20174-25-8 5-(5-bromo-furan-2-yl)-3-phenyl-4,5-dihydro-isoxazole 

Relevant articles and documents

Iron(iii)-catalyzed selective N-O bond cleavage to prepare tetrasubstituted pyridines and 3,5-disubstituted isoxazolines from: N -vinyl-α,β-unsaturated ketonitrones

An iron(iii)-catalyst controlled cyclization and selective N-O bond cleavage of N-vinyl-α,β-unsaturated nitrones has been achieved under mild conditions to access tetrasubstituted pyridines and 3,5-disubstituted isoxazolines in moderate to good yields. The tetrasubstituted pyridines were afforded with FeCl3 as a catalyst while using FeCl3·6H2O combined with 1,10-phenanthroline delivered isoxazolines. The regioselectivity for cyclization of styrenyl groups in N-vinyl-α,β-unsaturated nitrones was completely different during the formation of pyridines and isoxazolines. A rational mechanism for the formation of pyridines and isoxazolines was proposed based on the further control experimental studies. The isoxazolines can be converted to a novel bidentate N-ligand over four steps and an epoxypyridine scaffold was obtained from N-vinyl nitrone when copper(ii) acetate in combination with the prepared bidentate N-ligand was used.

3,4,5-trisubstituted-4,5-dihydroisoxazole, derivative and synthetic method and application thereof

The invention relates to 3,4,5-trisubstituted-4,5-dihydroisoxazole, a derivative and a synthetic method and an application thereof. The invention mainly relates to a synthetic method of an isoxazoline compound. With adoption of a technical scheme that an aldehyde compound and oxime ester are converted into isoxazoline and the derivative thereof by taking an organic solvent as a solvent under the action of alkali without using a catalyst, the synthetic method solves the problem that an existing synthetic method of the isoxazoline compound is complicated in synthetic step, is accomplished by adopting multiple steps, and also needs a metal catalyst, a chemically equivalent metal oxidant or a peroxide. The atom economy is kept to the extreme extent; the isoxazoline compound has a stable molecular structure and an excellent chemical property, and molecular slices and compound segments contain rich contents with biological activity and pharmacological activity. The isoxazoline compound also has the characteristics of being simple in reaction system, mild in reaction condition, relatively less in reaction equipment, simple in experimental operation, wide in source of materials, high in yield, easy for expansion of user and application, relatively high in utilization value of product and expectable in market commercial prospect.