2976-13-8

Upstream product

• 5910-23-6 1-furan-2-yl-3-phenyl-propane-1,3-dione 
• 2975-99-7 2-furyl phenylethynyl ketone 
• 98-80-6 phenylboronic acid 
• 13331-23-2 fur-2-ylboronic acid 
• 454253-30-6 trifluoromethanesulfonic acid 3-phenyl-isoxazol-5-yl ester 
• 1076-59-1 3-phenyl-4H-isoxazol-5-one 
• 527-69-5 2-furancarbonyl chloride 
• 536-74-3 phenylacetylene 
• 98-01-1 furfural 
• 717-21-5 3-(furan-1-yl)-1-phenyl-prop-2-en-1-one 
• 55367-28-7 5-(furan-2-yl)-3-phenyl-4,5-dihydroisoxazole 
• 94581-96-1 5-furan-2-yl-3-phenyl-4,5-dihydro-isoxazol-4-ol 

Downstream Products

• 2976-10-5 5-(5-bromo-furan-2-yl)-3-phenyl-isoxazole 
• 14442-12-7 3-phenylisoxazole-5-carboxylic acid 

Relevant academic research and scientific papers

Synthesis of isoxazoles via cyclization of β-fluoro enones with sodium azide

A practical method for the synthesis of 3,5-disubstituted isoxazoles via cyclization of β-fluoro enones with sodium azide was disclosed. Density functional theory (DFT) calculation indicated that both (1) the azirine formation followed by intramolecular rearrangement and (2) direct enolate O-attack via 5-exo-trig cyclization of vinyl azide were possible for the isoxazole formation.

General Platform for the Conversion of Isoxazol-5-ones to 3,5-Disubstituted Isoxazoles via Nucleophilic Substitutions and Palladium Catalyzed Cross-Coupling Strategies

A general platform for the conversion of isoxazol-5-ones to 3,5-disubstituted isoxazoles has been developed via a two-step strategy. The first step leads to the formation of 5-(pseudo)halogenated isoxazoles, while in the second, a variety of heteroalkyl-, heteroaryl-, alkyl-, alkenyl-, alkynyl- and aryl-chains can be installed via nucleophilic substitutions or palladium catalyzed cross-coupling reactions.

One-pot three-component synthesis of 3,5-disubstituted isoxazoles by a coupling-cyclocondensation sequence

A convenient one-pot procedure for the synthesis of 3,5-disubstituted isoxazoles from acid chloride, terminal alkyne, and hydroxylamine hydrochloride catalyzed by Pd(PPh3)2Cl2/CuI has been developed. The coupling of acid c

Preparation of 3,5-disubstituted pyrazoles and isoxazoles from terminal alkynes, aldehydes, hydrazines, and hydroxylamine

The reaction of terminal alkynes with n-BuLi, and then with aldehydes, followed by the treatment with molecular iodine, and subsequently hydrazines or hydroxylamine provided the corresponding 3,5-disubstituted pyrazoles or isoxazoles in good yields with high regioselectivity, through the formations of propargyl secondary alkoxides and α-alkynyl ketones. The present reactions are one-pot preparation of 3,5-disubstituted pyrazoles from terminal alkynes, aldehydes, molecular iodine, and hydrazines, and 3,5-disubstituted isoxazoles from terminal alkynes, aldehydes, molecular iodine, and hydroxylamine.

Synthesis of 3-Substituted 5-Arylisoxazoles from α,β-Unsaturated Oximes

The synthesis of 3-substituted 5-arylisoxazoles from oximes of α,β-unsaturated ketones is studied. The formation of the isoxazole derivatives takes place by cyclization of oximes in the presence of iodine and potassium iodide. The presence of isoxazoline