553672-06-3

Basic information

• Product Name: 5-Amino-3-cyclohexyl-1-methyl-1H-pyrazole-4-carboxamide
• Synonyms: 5-Amino-3-cyclohexyl-1-methyl-1H-pyrazole-4-carboxamide
• CAS NO: 553672-06-3
• Molecular Weight: 222.29
• Mol File: 553672-06-3.mol

Chemical Properties

• CAS DataBase Reference: 5-Amino-3-cyclohexyl-1-methyl-1H-pyrazole-4-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Amino-3-cyclohexyl-1-methyl-1H-pyrazole-4-carboxamide(553672-06-3)
• EPA Substance Registry System: 5-Amino-3-cyclohexyl-1-methyl-1H-pyrazole-4-carboxamide(553672-06-3)

Safety Data

• Hazardous Substances Data: 553672-06-3(Hazardous Substances Data)

Upstream product

• 553672-05-2 5-Amino-3-cyclohexyl-1-methyl-1H-pyrazole-4-carbonitrile 

Relevant articles and documents

PYRIDINYLPYRAZOLOPYRIMIDINONE DERIVATIVES AS PDE 7 INHIBITORS

To provide the compounds inhibiting PDE 7 selectively, and therefore, enhance cellular cAMP level. Consequently, the compound is useful for treating various kinds of disease such as allergic disease, inflammatory disease or immunologic disease. The compound is pyridinylpyrazolopyrimidinone compound represented by the following formula (IA) or (IB): especially, R1 is cyclohexyl or cycloheptyl group, R2 is methyl; R3 is a group: -NR5R6 or -S(O)0-2R8; hydrogen atom; nitro group; cyano group; a halogen atom; heteroaryl group; and R4 is methoxy or ethoxy group.

PYRAZOLOPYRIMIDINONE DERIVATIVES HAVING PDE7?INHIBITORY ACTIVITY

Pyrazolopyrimidinone derivatives expressed by the following general formula (IA) or (IB): and the following general formula (IA') or (IB'): where the symbols are as disclosed in the specification, are provided as desired compounds. These compounds have the action of selectively inhibiting PDE7, thereby increasing the intracellular cAMP level and inhibiting the activation of T cells. Thus, they are useful for prevention and treatment of various allergic diseases and inflammatory or immunological diseases.