553672-12-1

Basic information

• Product Name: benzyl 4-methoxypiperidine-1-carboxylate
• Synonyms: benzyl 4-methoxypiperidine-1-carboxylate
• CAS NO: 553672-12-1
• Molecular Weight: 249.31
• Mol File: 553672-12-1.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: benzyl 4-methoxypiperidine-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: benzyl 4-methoxypiperidine-1-carboxylate(553672-12-1)
• EPA Substance Registry System: benzyl 4-methoxypiperidine-1-carboxylate(553672-12-1)

Safety Data

• Hazardous Substances Data: 553672-12-1(Hazardous Substances Data)

Upstream product

• 95798-23-5 1-(benzyloxycarbonyl)-4-hydroxypiperidine 
• 74-88-4 methyl iodide 
• 4045-24-3 4-methoxypiperidine 
• 100-51-6 benzyl alcohol 
• 19099-93-5 benzyl 4-oxo-1-piperidinecarboxylate 

Downstream Products

• 553672-13-2 4-Methoxypiperidine p-toluenesulfonate 
• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 
• 19099-93-5 benzyl 4-oxo-1-piperidinecarboxylate 
• 924869-20-5 1-((4-nitrophenyl)sulfonyl)piperidin-4-one 
• 188622-27-7 tert-butyl 4-methoxypiperidine-1-carboxylate 
• 4045-24-3 4-methoxypiperidine 

Relevant articles and documents

Carbamate Synthesis Using a Shelf-Stable and Renewable C1 Reactant

4-Propylcatechol carbonate is a shelf-stable, renewable C1 reactant. It is easily prepared from renewable 4-propylcatechol (derived from wood) and dimethyl carbonate (derived from CO2) using a reactive distillation system. In this work, the 4-propylcatechol carbonate is used for the two-step synthesis of carbamates under mild reaction conditions. In the first step, 4-propylcatechol carbonate is treated with an alcohol at 50–80 °C in the presence of a Lewis acid catalyst, such as Zn(OAc)2?2 H2O. With liquid alcohols, no solvent is used and with solid alcohols 2-methyltetrahydrofuran is used as solvent. In the second step, the alkyl 2-hydroxy-propylphenyl carbonate intermediates obtained react with amines at room temperature in 2-methyltetrahydrofuran, forming the target carbamates and the byproduct 4-propylcatechol, which can be recycled into a carbonate reactant.

PYRAZOLE COMPOUNDS HAVING CANNABINOID RECEPTOR (CB1) ANTAGONIZING ACTIVITY

The present invention relates to a pyrazole compound having potent CB1-antagonizing activity, having the following formula [I]: wherein R1 and R2 are the same or different and an optionally substituted aryl group etc., R3 is an alkyl group etc., E is one of the following groups of the formula (i) to (iv): Q1 is a single bond, an alkylene group or a group of the formula: -N(R7)-, R7 is a hydrogen atom or an alkyl group, Q2 is a single bond, an oxygen atom or an alkylene group, R4 is a cycloalkyl group, a group of the formula: -N(R5)(R6) etc., one of R5 and R6 is a hydrogen atom or an alkyl group and the other is an alkyl group, a group of the formula: -N(R8)(R9) etc., D is an oxygen atom etc., RA1 is an amino group etc., RA2 is an optionally substituted aliphatic heterocyclic group, R is an alkyl group optionally substituted by one to three halogen atom(s) etc., one of R8 and R9 is a hydrogen atom or an alkyl group and the other is an alkyl group etc., or a pharmaceutically acceptable salt thereof.