4045-24-3

Basic information

• Product Name: 4-Methoxypiperidine
• Synonyms: 4-METHOXYPHENYLPHOSPHONICACID;4-methoxypiperidine(SALTDATA: HCl);Piperidine, 4-Methoxy-;4-Methoxypiperidine, 97+%;4-methoxy-1l2-piperidine;4-METHOXY-PIPERIDINE;4-MethoxyPiperazine;4-METHOXY-PIPERIDINE >98%
• CAS NO: 4045-24-3
• Molecular Formula: C₆H₁₃NO
• Molecular Weight: 115.17
• EINECS: 223-742-9
• Product Categories: Amines and Anilines;Piperidine
• Mol File: 4045-24-3.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 44°C/6.8mm
• Flash Point: 49.7 °C
• Appearance: Clear/Liquid
• Density: 0.93
• Vapor Pressure: 3.93mmHg at 25°C
• Storage Temp.: 2-8°C(protect from light)
• PKA: 9.83±0.10(Predicted)
• CAS DataBase Reference: 4-Methoxypiperidine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Methoxypiperidine(4045-24-3)
• EPA Substance Registry System: 4-Methoxypiperidine(4045-24-3)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22-20/21/22
• Safety Statements: 23-24/25
• RIDADR: 3267
• Hazardous Substances Data: 4045-24-3(Hazardous Substances Data)

Usage

Chemical Properties

Clear colorless liquid

InChI:InChI=1/C6H13NO.ClH/c1-8-6-2-4-7-5-3-6;/h6-7H,2-5H2,1H3;1H

Upstream product

• 124-41-4 sodium methylate 
• 109384-19-2 t-butyl 4-hydroxy piperidine-1-carboxylate 
• 188622-27-7 tert-butyl 4-methoxypiperidine-1-carboxylate 
• 4045-25-4 4-methoxypiperidine hydrochloride 
• 383865-57-4 4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl-amine 
• 141047-49-6 4-methoxy-piperidine-1-carbaldehyde 
• 620-08-6 4-methoxypyridine 
• 553672-12-1 benzyl 4-methoxypiperidine-1-carboxylate 

Downstream Products

• 97018-26-3 10-<3-(4-Methoxy-piperidino)-propyl>-phenoxazin 
• 141047-61-2 4-methoxypiperidine amide of L-phenyllactic acid 
• 221198-18-1 3-Fluoro-4-(4-methoxypiperidin-1-yl)nitrobenzene 
• 1247950-19-1 C₂₉H₃₆N₄O₄ 
• 1236356-58-3 4-amino-6-(4-{trans-4-[2-(4-methoxypiperidin-1-yl)-2-oxoethyl]cyclohexyl}phenyl)-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-5(6H)-one 
• 1362133-44-5 C₂₀H₂₃N₅O₄S 
• 1096789-62-6 C₁₃H₂₀N₂O₃S 

Relevant articles and documents

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Continuous flow hydrogenation of functionalized pyridines

The heterogeneous hydrogenation of substituted pyridines has been accomplished by employing a continuous flow hydrogenation device that incorporates in situ hydrogen generation by electrolysis of H20 and pre-packed catalyst cartridges. In general, the hydrogenation reactions proceeded smoothly regardless of the supported precious metal catalyst (Pd/C, Pt/C, or Rh/C). By using 30-80 bar of hydrogen pressure at 60-80 °C full conversion was typically achieved in all cases at a flow rate of 0.5 mL min -1, providing the corresponding piperidines in high yields. For disubstituted pyr idines, variations in stereoselectivity were observed depending on both the metal catalyst and the temperature/ pressure of the hydrogenation reaction. For ethyl nicotinate the selectivity between partial and full hydrogenation could be tuned depending on the hydrogen pressure, solvent, and the choice of supported metal catalyst. Changing the hydrogen source from H20 to D2C) allowed the preparation of de-uteriated derivatives. Wiley-VCH Verlag GmbH & Co. KGaA.

NOVEL 4-AMINO-THIENO[3,2-C]PYRIDINE-7-CARBOXYLIC ACID AMIDES

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